Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma

AbstractAsthma, as one of the most common chronic diseases in children and adults, is a consequence of complex gene –environment interactions. Polycyclic aromatic hydrocarbons (PAHs), as a group of widespread environmental organic pollutants, are involved in the development, triggering and pathologic changes of asthma. Various previous studies reported the critical roles of PAHs in immune changes, oxidative str ess and environment–gene interactions of asthma.EPHX1 (the gene of epoxide hydrolase 1, an enzyme mediating human PAH metabolism) had a possible association with asthma by influencing PAH metabolism. This review summarized that (1) the roles of PAHs in asthma —work as risk factors; (2) the possible mechanisms involved in PAH-related asthma—through immunologic and oxidative s...

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