Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment

Skeletal complications due to osteoporosis or bone metastases are associated with considerable pain, increased mortality, and reduced quality of life. Furthermore, such events place a burden on healthcare resources. Agents that prevent bone resorption such as bisphosphonates or denosumab can reduce the risk of skeletal-related events and are widely used in patients with osteoporosis or bone metastases. Medication-related osteonecrosis of the jaw (MRONJ) is a rare but potentially serious adverse event associated with high cumulative doses of bisphosphonates or denosumab.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ONO71q