Proteomic analysis of lipopolysaccharide activated human monocytes

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Mads Lausen, Thomas B.G. Poulsen, Gunna Christiansen, Kenneth Kastaniegaard, Allan Stensballe, Svend BirkelundAbstractMonocytes are key mediators of innate immunity and comprise an important cellular defence against invading pathogens. However, exaggerated or dysregulated monocyte activation can lead to severe immune-mediated pathology such as sepsis or chronic inflammatory diseases. Thus, detailed insight into the molecular mechanisms of monocyte activation is essential to understand monocyte-driven inflammatory pathologies. We therefore investigated the global protein changes in human monocytes during lipopolysaccharide (LPS) activation to mimic bacterial activation. Purified human monocytes were stimulated...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFFtfS