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We thank Xing et  al1 for their commentary regarding our recently published study, in which we found that a blood eosinophil count of greater than or equal to 300 cells/μL was predictive of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).2 Xing et al raise a question about the timing of the blood eosinophil measurements. In both the Genetic Epidemiology of COPD (COPDGene) and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) studies, complete blood cell counts (CBCs) were measured in clinically stable subjects. (Source: Journal of Allergy and Clinical Immunology)

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