Tres Hermanos Bakery Issues Allergy Alert on Undeclared Milk in Telera and Bolillo Breads

Tres Hermanos Bakery of Wyoming, MI is recalling its white Telera and Bolillo Mexican salt breads because they may contain undeclared milk. People who have allergies to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

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HAE Attacks Cut With Lanadelumab (CME/CE)

(MedPage Today) -- Improved quality of life across three doses for patients with hereditary angioedema (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E4etrn

Year in Review: Pulmonology

(MedPage Today) -- As-needed asthma therapy, peanut oral immunotherapy, teen e-cig use made headlines in 2018 (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SktKal

Tres Hermanos Bakery Issues Allergy Alert on Undeclared Milk in Telera and Bolillo Breads

Tres Hermanos Bakery of Wyoming, MI is recalling its white Telera and Bolillo Mexican salt breads because they may contain undeclared milk. People who have allergies to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rnb8GJ

HAE Attacks Cut With Lanadelumab (CME/CE)

(MedPage Today) -- Improved quality of life across three doses for patients with hereditary angioedema (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E4etrn

Year in Review: Pulmonology

(MedPage Today) -- As-needed asthma therapy, peanut oral immunotherapy, teen e-cig use made headlines in 2018 (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SktKal

Tres Hermanos Bakery Issues Allergy Alert on Undeclared Milk in Telera and Bolillo Breads

Tres Hermanos Bakery of Wyoming, MI is recalling its white Telera and Bolillo Mexican salt breads because they may contain undeclared milk. People who have allergies to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rnb8GJ

HAE Attacks Cut With Lanadelumab (CME/CE)

(MedPage Today) -- Improved quality of life across three doses for patients with hereditary angioedema (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E4etrn

Year in Review: Pulmonology

(MedPage Today) -- As-needed asthma therapy, peanut oral immunotherapy, teen e-cig use made headlines in 2018 (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SktKal

Tres Hermanos Bakery Issues Allergy Alert on Undeclared Milk in Telera and Bolillo Breads

Tres Hermanos Bakery of Wyoming, MI is recalling its white Telera and Bolillo Mexican salt breads because they may contain undeclared milk. People who have allergies to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rnb8GJ

HAE Attacks Cut With Lanadelumab (CME/CE)

(MedPage Today) -- Improved quality of life across three doses for patients with hereditary angioedema (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E4etrn

Year in Review: Pulmonology

(MedPage Today) -- As-needed asthma therapy, peanut oral immunotherapy, teen e-cig use made headlines in 2018 (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SktKal

Balancing Screen Time Use With Young Clients and Their Parents

As my husband and I sat in a local restaurant, I took note of all the little heads dozing into screens and exclaimed, "My child will never do that!" Sound familiar? I not only swallowed my pride time and time again as a parent, but I've also done it as a speech-language pathologist. I once found it easy to instruct parents on the dangers of digital media and the never-appropriate use for it at the dinner table. Now with two children of my own, both younger than 5, I know first-hand about the allure of digital media. Digital media is part of our world. SLPs can't ignore the role devices, screens, apps, and other digital forms of entertainment and education play as today's children learn language. In the Age of Technology, Who Better to Educate on Safe Use Than You? Tots as Young ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U1ynb1

Balancing Screen Time Use With Young Clients and Their Parents

As my husband and I sat in a local restaurant, I took note of all the little heads dozing into screens and exclaimed, "My child will never do that!" Sound familiar? I not only swallowed my pride time and time again as a parent, but I've also done it as a speech-language pathologist. I once found it easy to instruct parents on the dangers of digital media and the never-appropriate use for it at the dinner table. Now with two children of my own, both younger than 5, I know first-hand about the allure of digital media. Digital media is part of our world. SLPs can't ignore the role devices, screens, apps, and other digital forms of entertainment and education play as today's children learn language. In the Age of Technology, Who Better to Educate on Safe Use Than You? Tots as Young ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U1ynb1

Balancing Screen Time Use With Young Clients and Their Parents

As my husband and I sat in a local restaurant, I took note of all the little heads dozing into screens and exclaimed, "My child will never do that!" Sound familiar? I not only swallowed my pride time and time again as a parent, but I've also done it as a speech-language pathologist. I once found it easy to instruct parents on the dangers of digital media and the never-appropriate use for it at the dinner table. Now with two children of my own, both younger than 5, I know first-hand about the allure of digital media. Digital media is part of our world. SLPs can't ignore the role devices, screens, apps, and other digital forms of entertainment and education play as today's children learn language. In the Age of Technology, Who Better to Educate on Safe Use Than You? Tots as Young ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U1ynb1

Balancing Screen Time Use With Young Clients and Their Parents

As my husband and I sat in a local restaurant, I took note of all the little heads dozing into screens and exclaimed, "My child will never do that!" Sound familiar? I not only swallowed my pride time and time again as a parent, but I've also done it as a speech-language pathologist. I once found it easy to instruct parents on the dangers of digital media and the never-appropriate use for it at the dinner table. Now with two children of my own, both younger than 5, I know first-hand about the allure of digital media. Digital media is part of our world. SLPs can't ignore the role devices, screens, apps, and other digital forms of entertainment and education play as today's children learn language. In the Age of Technology, Who Better to Educate on Safe Use Than You? Tots as Young ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U1ynb1

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q48jOn

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q48jOn

Assessing the effects of long-term osteoporosis treatment by using conventional spine radiographs: results from a pilot study in a sub-cohort of a large randomized controlled trial

Abstract

Objective

To evaluate the clinical applicability of a software tool developed to extract bone textural information from conventional lumbar spine radiographs, and to test it in a subset of postmenopausal women treated for osteoporosis with the fully human monoclonal antibody denosumab.

Methods

The software was developed based on the principles of a fractal model using pixel grey-level variations together with a specific machine-learning algorithm. The obtained dimensionless parameter, termed bone structure value (BSV), was then tested and compared to bone mineral density (BMD) in a sub-cohort of postmenopausal women with osteoporosis who were treated with the monoclonal antibody denosumab, within the framework of a large randomized controlled trial and its open-label extension phase.

Results

After 3 years and after 8 years of treatment with denosumab, mean lumbar spine BMD as well as mean lumbar BSV were significantly higher compared to study entry (one-way repeated measures ANOVA for DXA: F = 108.2, p < 0.00001; and for BSV: F = 84.3, p < 0.00001). The overall increase in DXA-derived lumbar spine BMD at year 8 was + 42% (mean ± SD; 0.725 ± 0.038 g/cm² to 1.031 ± 0.092 g/cm²; p < 0.0001), and the overall increase of BSV was 255% (mean ± SD; 0.076 ± 0.022 to 0.270 ± 0.09, p < 0.0001). Overall, BMD and BSV were significantly correlated (R = 0.51; p < 0.0001).

Conclusions

This pilot study provides evidence that lumbar spine BSV as obtained from conventional radiographs constitutes a useful means for the assessment of bone-specific treatment effects in postmenopausal women with osteoporosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PbAbuh

Assessing the effects of long-term osteoporosis treatment by using conventional spine radiographs: results from a pilot study in a sub-cohort of a large randomized controlled trial

Abstract

Objective

To evaluate the clinical applicability of a software tool developed to extract bone textural information from conventional lumbar spine radiographs, and to test it in a subset of postmenopausal women treated for osteoporosis with the fully human monoclonal antibody denosumab.

Methods

The software was developed based on the principles of a fractal model using pixel grey-level variations together with a specific machine-learning algorithm. The obtained dimensionless parameter, termed bone structure value (BSV), was then tested and compared to bone mineral density (BMD) in a sub-cohort of postmenopausal women with osteoporosis who were treated with the monoclonal antibody denosumab, within the framework of a large randomized controlled trial and its open-label extension phase.

Results

After 3 years and after 8 years of treatment with denosumab, mean lumbar spine BMD as well as mean lumbar BSV were significantly higher compared to study entry (one-way repeated measures ANOVA for DXA: F = 108.2, p < 0.00001; and for BSV: F = 84.3, p < 0.00001). The overall increase in DXA-derived lumbar spine BMD at year 8 was + 42% (mean ± SD; 0.725 ± 0.038 g/cm² to 1.031 ± 0.092 g/cm²; p < 0.0001), and the overall increase of BSV was 255% (mean ± SD; 0.076 ± 0.022 to 0.270 ± 0.09, p < 0.0001). Overall, BMD and BSV were significantly correlated (R = 0.51; p < 0.0001).

Conclusions

This pilot study provides evidence that lumbar spine BSV as obtained from conventional radiographs constitutes a useful means for the assessment of bone-specific treatment effects in postmenopausal women with osteoporosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PbAbuh

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sk6rgQ

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sk6rgQ

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sk6rgQ

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sk6rgQ

Balancing Screen Time Use With Young Clients and Their Parents

As my husband and I sat in a local restaurant, I took note of all the little heads dozing into screens and exclaimed, "My child will never do that!" Sound familiar? I not only swallowed my pride time and time again as a parent, but I've also done it as a speech-language pathologist. I once found it easy to instruct parents on the dangers of digital media and the never-appropriate use for it at the dinner table. Now with two children of my own, both younger than 5, I know first-hand about the allure of digital media. Digital media is part of our world. SLPs can't ignore the role devices, screens, apps, and other digital forms of entertainment and education play as today's children learn language. In the Age of Technology, Who Better to Educate on Safe Use Than You? Tots as Young ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U1ynb1

TYLENOL ® Recognizes and Supports Caregivers with #HowWeCare

Sponsored Part of the caregiving experience seems to be a deep need for caregivers to share their stories. This desire stems from wanting others to know about the joys and sorrows of caregiving as well as an ongoing need to help others. TYLENOL® recognizes this and wants to support caregivers not only during National Family Caregivers Month but afterward by providing, through their #HowWeCare campaign, a forum for caregivers to share their stories with larger audiences than they might otherwise have the opportunity to reach. The company recognizes that providing care for a loved one with a health condition is a challenging role that people don't necessarily ask for and often don't expect. They have stepped forward to support and acknowledge the 34 million Americans who ha...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ADALMd

Balancing Screen Time Use With Young Clients and Their Parents

As my husband and I sat in a local restaurant, I took note of all the little heads dozing into screens and exclaimed, "My child will never do that!" Sound familiar? I not only swallowed my pride time and time again as a parent, but I've also done it as a speech-language pathologist. I once found it easy to instruct parents on the dangers of digital media and the never-appropriate use for it at the dinner table. Now with two children of my own, both younger than 5, I know first-hand about the allure of digital media. Digital media is part of our world. SLPs can't ignore the role devices, screens, apps, and other digital forms of entertainment and education play as today's children learn language. In the Age of Technology, Who Better to Educate on Safe Use Than You? Tots as Young ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U1ynb1

TYLENOL ® Recognizes and Supports Caregivers with #HowWeCare

Sponsored Part of the caregiving experience seems to be a deep need for caregivers to share their stories. This desire stems from wanting others to know about the joys and sorrows of caregiving as well as an ongoing need to help others. TYLENOL® recognizes this and wants to support caregivers not only during National Family Caregivers Month but afterward by providing, through their #HowWeCare campaign, a forum for caregivers to share their stories with larger audiences than they might otherwise have the opportunity to reach. The company recognizes that providing care for a loved one with a health condition is a challenging role that people don't necessarily ask for and often don't expect. They have stepped forward to support and acknowledge the 34 million Americans who ha...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ADALMd

Split-mouth evaluation of connective tissue graft with or without enamel matrix derivative for the treatment of isolated gingival recession defects in dogs

Abstract

Objectives

The potential additive effect of an enamel matrix derivative (EMD) to a subepithelial connective tissue graft (CTG) for recession coverage is still controversially discussed. Therefore, the aim of this study was to histologically evaluate the healing of gingival recessions treated with coronally advanced flap (CAF) and CTG with or without EMD in dogs.

Materials and methods

Gingival recession defects (5 mm wide and 7 mm deep) were surgically created on the labial side of bilateral maxillary canines in 7 dogs. After 8 weeks of plaque accumulation and subsequent 2 weeks of chemical plaque control, the 14 chronic defects were randomized to receive either CAF with CTG (CAF/CTG) or CAF with CTG and EMD (CAF/CTG/EMD). The animals were sacrificed 10 weeks after reconstructive surgery for histologic evaluation.

Results

Treatment with CAF/CTG/EMD demonstrated statistically significantly better results in terms of probing pocket depth reduction (P < 0.05) and clinical attachment level gain (P < 0.001). The length of the epithelium was statistically significantly shorter in the CAF/CTG/EMD group than in the CAF/CTG group (1.00 ± 0.75 mm vs. 2.38 ± 1.48 mm, respectively, P < 0.01). Cementum formation was statistically significantly greater in the CAF/CTG/EMD group than following treatment with the CAF/CTG group (3.20 ± 0.89 mm vs. 1.88 ± 1.58 mm, respectively, P < 0.01). The CAF/CTG/EMD group showed statistically significantly greater complete periodontal regeneration (i.e., new cementum, new periodontal ligament, and new bone) than treatment with CAF/CTG (0.54 ± 0.73 mm vs. 0.07 ± 0.27 mm, respectively, P < 0.05).

Conclusion

Within their limits, the present findings indicate that the additional use of EMD in conjunction with CAF + CTG favors periodontal regeneration in gingival recession defects.

Clinical relevance

The present findings support the use of EMD combined with CTG and CAF for promoting periodontal regeneration in isolated gingival recession defects.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E9eZV5

Split-mouth evaluation of connective tissue graft with or without enamel matrix derivative for the treatment of isolated gingival recession defects in dogs

Abstract

Objectives

The potential additive effect of an enamel matrix derivative (EMD) to a subepithelial connective tissue graft (CTG) for recession coverage is still controversially discussed. Therefore, the aim of this study was to histologically evaluate the healing of gingival recessions treated with coronally advanced flap (CAF) and CTG with or without EMD in dogs.

Materials and methods

Gingival recession defects (5 mm wide and 7 mm deep) were surgically created on the labial side of bilateral maxillary canines in 7 dogs. After 8 weeks of plaque accumulation and subsequent 2 weeks of chemical plaque control, the 14 chronic defects were randomized to receive either CAF with CTG (CAF/CTG) or CAF with CTG and EMD (CAF/CTG/EMD). The animals were sacrificed 10 weeks after reconstructive surgery for histologic evaluation.

Results

Treatment with CAF/CTG/EMD demonstrated statistically significantly better results in terms of probing pocket depth reduction (P < 0.05) and clinical attachment level gain (P < 0.001). The length of the epithelium was statistically significantly shorter in the CAF/CTG/EMD group than in the CAF/CTG group (1.00 ± 0.75 mm vs. 2.38 ± 1.48 mm, respectively, P < 0.01). Cementum formation was statistically significantly greater in the CAF/CTG/EMD group than following treatment with the CAF/CTG group (3.20 ± 0.89 mm vs. 1.88 ± 1.58 mm, respectively, P < 0.01). The CAF/CTG/EMD group showed statistically significantly greater complete periodontal regeneration (i.e., new cementum, new periodontal ligament, and new bone) than treatment with CAF/CTG (0.54 ± 0.73 mm vs. 0.07 ± 0.27 mm, respectively, P < 0.05).

Conclusion

Within their limits, the present findings indicate that the additional use of EMD in conjunction with CAF + CTG favors periodontal regeneration in gingival recession defects.

Clinical relevance

The present findings support the use of EMD combined with CTG and CAF for promoting periodontal regeneration in isolated gingival recession defects.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E9eZV5

Comment on “Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm”

I read with great excitement the recent "Perspectives" article by Jazayeri and Chuang,1 "Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm." I have shared this same ideology since being a resident myself, when I struggled to find a research mentor. There was no emphasis on research by my clinical faculty, and given the mere half page of importance placed on research and academic productivity by the Commission on Dental Accreditation (CODA), it is not hard to see why.

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Comment on “Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm”

I read with great excitement the recent "Perspectives" article by Jazayeri and Chuang,1 "Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm." I have shared this same ideology since being a resident myself, when I struggled to find a research mentor. There was no emphasis on research by my clinical faculty, and given the mere half page of importance placed on research and academic productivity by the Commission on Dental Accreditation (CODA), it is not hard to see why.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zzWaWR

4-D flow magnetic-resonance-imaging-derived energetic biomarkers are abnormal in children with repaired tetralogy of Fallot and associated with disease severity

Abstract

Background

Cardiac MRI plays a central role in monitoring children with repaired tetralogy of Fallot (TOF) for long-term complications. Current risk assessment is based on volumetric and functional parameters that measure late expression of underlying physiological changes. Emerging 4-D flow MRI techniques promise new insights.

Objective

To assess whether 4-D flow MRI-derived measures of blood kinetic energy (1) differentiate children and young adults with TOF from controls and (2) are associated with disease severity.

Materials and methods

Pediatric patients post TOF repair (n=21) and controls (n=24) underwent 4-D flow MRI for assessment of time-resolved 3-D blood flow. Data analysis included 3-D segmentation of the right ventricle (RV) and pulmonary artery (PA), with calculation of peak systolic and diastolic kinetic energy (KE) maps. Total KE_RV and KE_PA were determined from the sum of the KE of all voxels within the respective time-resolved segmentations.

Results

KE_PA was increased in children post TOF vs. controls across the cardiac cycle, with median 12.5 (interquartile range [IQR] 10.3) mJ/m² vs. 8.2 (4.3) mJ/m², P<0.01 in systole; and 2.3 (2.7) mJ/m² vs. 1.4 (0.9) mJ/m², P<0.01 in diastole. Diastolic KE_PA correlated with systolic KE_PA (R² 0.41, P<0.01) and with pulmonary regurgitation fraction (R² 0.65, P<0.01). Diastolic KE_RV showed similar relationships, denoting increasing KE with higher cardiac outputs and increased right heart volume loading. Diastolic KE_RV and KE_PA increased with RV end-diastolic volume in a non-linear relationship (R² 0.33, P<0.01 and R² 0.50, P<0.01 respectively), with an inflection point near 120 mL/m².

Conclusion

Four-dimensional flow-derived KE is abnormal in pediatric patients post TOF repair compared to controls and has a direct, non-linear relationship with traditional measures of disease progression. Future longitudinal studies are needed to evaluate utility for early outcome prediction in TOF.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zygbx8

4-D flow magnetic-resonance-imaging-derived energetic biomarkers are abnormal in children with repaired tetralogy of Fallot and associated with disease severity

Abstract

Background

Cardiac MRI plays a central role in monitoring children with repaired tetralogy of Fallot (TOF) for long-term complications. Current risk assessment is based on volumetric and functional parameters that measure late expression of underlying physiological changes. Emerging 4-D flow MRI techniques promise new insights.

Objective

To assess whether 4-D flow MRI-derived measures of blood kinetic energy (1) differentiate children and young adults with TOF from controls and (2) are associated with disease severity.

Materials and methods

Pediatric patients post TOF repair (n=21) and controls (n=24) underwent 4-D flow MRI for assessment of time-resolved 3-D blood flow. Data analysis included 3-D segmentation of the right ventricle (RV) and pulmonary artery (PA), with calculation of peak systolic and diastolic kinetic energy (KE) maps. Total KE_RV and KE_PA were determined from the sum of the KE of all voxels within the respective time-resolved segmentations.

Results

KE_PA was increased in children post TOF vs. controls across the cardiac cycle, with median 12.5 (interquartile range [IQR] 10.3) mJ/m² vs. 8.2 (4.3) mJ/m², P<0.01 in systole; and 2.3 (2.7) mJ/m² vs. 1.4 (0.9) mJ/m², P<0.01 in diastole. Diastolic KE_PA correlated with systolic KE_PA (R² 0.41, P<0.01) and with pulmonary regurgitation fraction (R² 0.65, P<0.01). Diastolic KE_RV showed similar relationships, denoting increasing KE with higher cardiac outputs and increased right heart volume loading. Diastolic KE_RV and KE_PA increased with RV end-diastolic volume in a non-linear relationship (R² 0.33, P<0.01 and R² 0.50, P<0.01 respectively), with an inflection point near 120 mL/m².

Conclusion

Four-dimensional flow-derived KE is abnormal in pediatric patients post TOF repair compared to controls and has a direct, non-linear relationship with traditional measures of disease progression. Future longitudinal studies are needed to evaluate utility for early outcome prediction in TOF.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zygbx8

B-Cell Receptor-Associated Protein 31 Regulates the Expression of Valosin-Containing Protein Through Elf2

Conclusion: These results indicate that Bap31 regulates the expression of VCP possibly via Elf2 and support the potential molecular function of Bap31 in CNS diseases.Cell Physiol Biochem 2018;51:1799 –1814 (Source: Cellular Physiology and Biochemistry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Age-Related Changes in Ang II Receptor Localization and Expression in the Developing Auditory Pathway.

Authors: Arce ME, Sánchez SI, Correa MM, Ciuffo GM Abstract We studied Ang II receptor localization in different nuclei of the auditory system, by means of binding autoradiography, during brain development. The inferior colliculus (IC), a large midbrain structure which serves as an obligatory synaptic station in both the ascending and descending auditory pathways, exhibited high Ang II AT2 binding at all ages (P0, P8, P15, P30), being maximal at P15. These observations were confirmed by in situ hybridization and immunofluorescence at P15, demonstrating that AT2 receptor mRNA localized at the same area recognized by AT2 antibodies and anti β III-tubulin suggesting the neuronal nature of the reactive cells. Ang II AT1 receptors were absent at early developmental ages (P0) in all nu...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BIww3G

B-Cell Receptor-Associated Protein 31 Regulates the Expression of Valosin-Containing Protein Through Elf2

Conclusion: These results indicate that Bap31 regulates the expression of VCP possibly via Elf2 and support the potential molecular function of Bap31 in CNS diseases.Cell Physiol Biochem 2018;51:1799 –1814 (Source: Cellular Physiology and Biochemistry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KK4ojG

Age-Related Changes in Ang II Receptor Localization and Expression in the Developing Auditory Pathway.

Authors: Arce ME, Sánchez SI, Correa MM, Ciuffo GM Abstract We studied Ang II receptor localization in different nuclei of the auditory system, by means of binding autoradiography, during brain development. The inferior colliculus (IC), a large midbrain structure which serves as an obligatory synaptic station in both the ascending and descending auditory pathways, exhibited high Ang II AT2 binding at all ages (P0, P8, P15, P30), being maximal at P15. These observations were confirmed by in situ hybridization and immunofluorescence at P15, demonstrating that AT2 receptor mRNA localized at the same area recognized by AT2 antibodies and anti β III-tubulin suggesting the neuronal nature of the reactive cells. Ang II AT1 receptors were absent at early developmental ages (P0) in all nu...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BIww3G

Comment on “Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm”

I read with great excitement the recent "Perspectives" article by Jazayeri and Chuang,1 "Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm." I have shared this same ideology since being a resident myself, when I struggled to find a research mentor. There was no emphasis on research by my clinical faculty, and given the mere half page of importance placed on research and academic productivity by the Commission on Dental Accreditation (CODA), it is not hard to see why.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zzWaWR

Comment on “Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm”

I read with great excitement the recent "Perspectives" article by Jazayeri and Chuang,1 "Transitioning From Commission on Dental Accreditation to Accreditation Council for Graduate Medical Education Standards of Academic Productivity: A New Paradigm." I have shared this same ideology since being a resident myself, when I struggled to find a research mentor. There was no emphasis on research by my clinical faculty, and given the mere half page of importance placed on research and academic productivity by the Commission on Dental Accreditation (CODA), it is not hard to see why.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zzWaWR

HAE Attacks Cut With Lanadelumab (CME/CE)

(MedPage Today) -- Improved quality of life across three doses for patients with hereditary angioedema (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E4etrn

Year in Review: Pulmonology

(MedPage Today) -- As-needed asthma therapy, peanut oral immunotherapy, teen e-cig use made headlines in 2018 (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SktKal

HAE Attacks Cut With Lanadelumab (CME/CE)

(MedPage Today) -- Improved quality of life across three doses for patients with hereditary angioedema (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E4etrn

Year in Review: Pulmonology

(MedPage Today) -- As-needed asthma therapy, peanut oral immunotherapy, teen e-cig use made headlines in 2018 (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SktKal

Styloid-stylohyoid syndrome: a rare cause of cranio-facial pain —a retrospective case series of 12 patients

ConclusionsTranscervical styloidectomy is an effective treatment for exposure and resection of the styloid process with minimal complications in patients with stylo-stylohyoid syndrome. (Source: Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zAwUjw

Styloid-stylohyoid syndrome: a rare cause of cranio-facial pain —a retrospective case series of 12 patients

ConclusionsTranscervical styloidectomy is an effective treatment for exposure and resection of the styloid process with minimal complications in patients with stylo-stylohyoid syndrome. (Source: Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zAwUjw

Industry payments in oral and maxillofacial surgery: a review of 112,478 payments from a national disclosure program

The purpose of this study was to characterize the sources, amounts, and nature of general industry payments to oral and maxillofacial surgeons (OMSs).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qq6niy

Commentary: Propofol Versus Remifentanil: Which One Is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial

We recently read the article by Eshghpour et al., "Propofol versus Remifentanil: Which One is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial."1 As a center that performs a high volume of orthognathic surgical procedures annually, we were very interested in this work as it purports to present high-level evidence for minimizing blood loss during these operations. However, upon critically evaluating the work, we identified several issues that may preclude acceptance of the authors' stated conclusions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DVpFFx

Multiple calcifying hyperplastic dental follicles: a case report

Multiple calcifying hyperplastic dental follicles (MCHDF) is a rare condition of calcification in follicles of multiple impacted teeth. Radiologically it appears as multiple pericoronal radiolucencies with radiopaque foci. This report presents a case of MCHDF in a 22-year-old male.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DSxk7H

Buccinator and Mandibular Node Metastases in Oral Squamous Cell Carcinoma

The buccinator and mandibular nodes both belong to the facial lymph node group, and metastasis of oral cancer to these nodes is extremely rare. The purpose of this study was to indicate the particular rare metastasis cases wherein we administered treatment for the buccinator or mandibular nodes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QrgWBJ

Industry payments in oral and maxillofacial surgery: a review of 112,478 payments from a national disclosure program

The purpose of this study was to characterize the sources, amounts, and nature of general industry payments to oral and maxillofacial surgeons (OMSs).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qq6niy

Commentary: Propofol Versus Remifentanil: Which One Is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial

We recently read the article by Eshghpour et al., "Propofol versus Remifentanil: Which One is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial."1 As a center that performs a high volume of orthognathic surgical procedures annually, we were very interested in this work as it purports to present high-level evidence for minimizing blood loss during these operations. However, upon critically evaluating the work, we identified several issues that may preclude acceptance of the authors' stated conclusions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DVpFFx

Multiple calcifying hyperplastic dental follicles: a case report

Multiple calcifying hyperplastic dental follicles (MCHDF) is a rare condition of calcification in follicles of multiple impacted teeth. Radiologically it appears as multiple pericoronal radiolucencies with radiopaque foci. This report presents a case of MCHDF in a 22-year-old male.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DSxk7H

Buccinator and Mandibular Node Metastases in Oral Squamous Cell Carcinoma

The buccinator and mandibular nodes both belong to the facial lymph node group, and metastasis of oral cancer to these nodes is extremely rare. The purpose of this study was to indicate the particular rare metastasis cases wherein we administered treatment for the buccinator or mandibular nodes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QrgWBJ

Thyroid malignancy among patients with thyroid nodules in the United Arab Emirates: a five-year retrospective tertiary Centre analysis

Abstract

Objectives

Thyroid malignancy constitutes the sixth common cancer type in the United Arab Emirates (UAE). There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultra-sonographic features correlating with thyroid malignancy in the UAE. This study aimed to estimate the prevalence of thyroid malignancy in patients with thyroid nodules and to describe the ultra-sonographic characteristics of thyroid nodules harbouring malignancy.

Methods

A retrospective electronic medical records review of all thyroid nodules in patients (aged 18 to 80 years) with normal thyroid-stimulating hormone (TSH) levels, who underwent ultrasound guided fine needle aspiration cytology (UG-FNA) at Sheikh Khalifa Medical City (SKMC) during 2011–2015.

Results

436 patients with normal TSH underwent UG-FNA cytological examination of thyroid nodules (n = 555 nodules). The overall crude prevalence of thyroid cancer among patients was 10.1% (95% CI 7.5–13.3). The age-adjusted prevalence of thyroid cancer among UAE nationals, Arabs, Far East Asians, and Caucasians were 9.6% (3.6–15.6), 10.0% (6.2–13.8), 16.8% (4.5–29.0) and 16.3% (1.7–30.9), respectively. The crude prevalence was 14.5%(95% CI 6.2–22.8) in men, and 9.3%(95% CI 6.3–12.2) in women. The echogenicity features were significantly different between the cancerous and noncancerous nodules (p = 0.025). Cancerous nodules were relatively more hyper- and hypo-echoic, while noncancerous nodules were mostly complex.

Conclusion

We report a higher prevalence of thyroid malignancy among patients with thyroid nodules relative to that reported in other parts of the world. The rate of thyroid malignancy was higher in patients of Far-East Asian and Caucasian ethnic background.

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Excessive $48,329 Charge for California Patient ’s Outpatient Clinical Laboratory Testing Calls Attention to Chargemaster Rates and New CMS Price Transparency Rule

Studies show medical laboratories may be particularly hit by adjustments to hospital chargemasters as hospitals prepare to comply with Medicare's New Transparency Rule Recently, Kaiser Health News (KHN) published a story about a $48,329 bill for allergy testing that cast a spotlight on hospital chargemaster rates just as healthcare providers are preparing to publish their […] (Source: Dark Daily)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6dcq3

Thyroid malignancy among patients with thyroid nodules in the United Arab Emirates: a five-year retrospective tertiary Centre analysis

Abstract

Objectives

Thyroid malignancy constitutes the sixth common cancer type in the United Arab Emirates (UAE). There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultra-sonographic features correlating with thyroid malignancy in the UAE. This study aimed to estimate the prevalence of thyroid malignancy in patients with thyroid nodules and to describe the ultra-sonographic characteristics of thyroid nodules harbouring malignancy.

Methods

A retrospective electronic medical records review of all thyroid nodules in patients (aged 18 to 80 years) with normal thyroid-stimulating hormone (TSH) levels, who underwent ultrasound guided fine needle aspiration cytology (UG-FNA) at Sheikh Khalifa Medical City (SKMC) during 2011–2015.

Results

436 patients with normal TSH underwent UG-FNA cytological examination of thyroid nodules (n = 555 nodules). The overall crude prevalence of thyroid cancer among patients was 10.1% (95% CI 7.5–13.3). The age-adjusted prevalence of thyroid cancer among UAE nationals, Arabs, Far East Asians, and Caucasians were 9.6% (3.6–15.6), 10.0% (6.2–13.8), 16.8% (4.5–29.0) and 16.3% (1.7–30.9), respectively. The crude prevalence was 14.5%(95% CI 6.2–22.8) in men, and 9.3%(95% CI 6.3–12.2) in women. The echogenicity features were significantly different between the cancerous and noncancerous nodules (p = 0.025). Cancerous nodules were relatively more hyper- and hypo-echoic, while noncancerous nodules were mostly complex.

Conclusion

We report a higher prevalence of thyroid malignancy among patients with thyroid nodules relative to that reported in other parts of the world. The rate of thyroid malignancy was higher in patients of Far-East Asian and Caucasian ethnic background.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FNGRj3

Excessive $48,329 Charge for California Patient ’s Outpatient Clinical Laboratory Testing Calls Attention to Chargemaster Rates and New CMS Price Transparency Rule

Studies show medical laboratories may be particularly hit by adjustments to hospital chargemasters as hospitals prepare to comply with Medicare's New Transparency Rule Recently, Kaiser Health News (KHN) published a story about a $48,329 bill for allergy testing that cast a spotlight on hospital chargemaster rates just as healthcare providers are preparing to publish their […] (Source: Dark Daily)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6dcq3

Interferon-lambda1 enhances Staphylococcus aureus clearance in healthy nasal mucosa, not in nasal polyps

IFN- λ1 has anti-bacterial activity, and favors the clearance of S. aureus in human nasal mucosa of healthy subjects by various mechanisms, which do not work in nasal polyposis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RrVKc0

Sublingual allergen immunotherapy with a liquid birch pollen product in seasonal allergic rhinoconjunctivitis with/without asthma*

The current pivotal phase III study confirmed clinical efficacy as well as safety of a high-dose liquid SLIT product. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6dc9x

Excessive $48,329 Charge for California Patient ’s Outpatient Clinical Laboratory Testing Calls Attention to Chargemaster Rates and New CMS Price Transparency Rule

Studies show medical laboratories may be particularly hit by adjustments to hospital chargemasters as hospitals prepare to comply with Medicare's New Transparency Rule Recently, Kaiser Health News (KHN) published a story about a $48,329 bill for allergy testing that cast a spotlight on hospital chargemaster rates just as healthcare providers are preparing to publish their […] (Source: Dark Daily)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6dcq3

Excessive $48,329 Charge for California Patient ’s Outpatient Clinical Laboratory Testing Calls Attention to Chargemaster Rates and New CMS Price Transparency Rule

Studies show medical laboratories may be particularly hit by adjustments to hospital chargemasters as hospitals prepare to comply with Medicare's New Transparency Rule Recently, Kaiser Health News (KHN) published a story about a $48,329 bill for allergy testing that cast a spotlight on hospital chargemaster rates just as healthcare providers are preparing to publish their […] (Source: Dark Daily)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6dcq3

Interferon-lambda1 enhances Staphylococcus aureus clearance in healthy nasal mucosa, not in nasal polyps

IFN- λ1 has anti-bacterial activity, and favors the clearance of S. aureus in human nasal mucosa of healthy subjects by various mechanisms, which do not work in nasal polyposis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RrVKc0

Sublingual allergen immunotherapy with a liquid birch pollen product in seasonal allergic rhinoconjunctivitis with/without asthma*

The current pivotal phase III study confirmed clinical efficacy as well as safety of a high-dose liquid SLIT product. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6dc9x

Switched CD21 –/low B cells with an antigen-presenting phenotype in the infant thymus

Half of all B cells in the human thymus are mature CD21 –/low AIRE-expressing cells with a professional antigen presenting cell phenotype, implying a role in T-cell selection and therefore critical in preventing autoimmunity. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rq6yYp

Switched CD21 –/low B cells with an antigen-presenting phenotype in the infant thymus

Half of all B cells in the human thymus are mature CD21 –/low AIRE-expressing cells with a professional antigen presenting cell phenotype, implying a role in T-cell selection and therefore critical in preventing autoimmunity. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rq6yYp

Switched CD21–/low B cells with an antigen-presenting phenotype in the infant thymus

Half of all B cells in the human thymus are mature CD21–/low AIRE-expressing cells with a professional antigen presenting cell phenotype, implying a role in T-cell selection and therefore critical in preventing autoimmunity.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KJNSjG

Sublingual allergen immunotherapy with a liquid birch pollen product in seasonal allergic rhinoconjunctivitis with/without asthma*

The current pivotal phase III study confirmed clinical efficacy as well as safety of a high-dose liquid SLIT product.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BKrqnE

Interferon-lambda1 enhances Staphylococcus aureus clearance in healthy nasal mucosa, not in nasal polyps

IFN-λ1 has anti-bacterial activity, and favors the clearance of S. aureus in human nasal mucosa of healthy subjects by various mechanisms, which do not work in nasal polyposis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KJNOAs

Switched CD21–/low B cells with an antigen-presenting phenotype in the infant thymus

Half of all B cells in the human thymus are mature CD21–/low AIRE-expressing cells with a professional antigen presenting cell phenotype, implying a role in T-cell selection and therefore critical in preventing autoimmunity.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KJNSjG

Sublingual allergen immunotherapy with a liquid birch pollen product in seasonal allergic rhinoconjunctivitis with/without asthma*

The current pivotal phase III study confirmed clinical efficacy as well as safety of a high-dose liquid SLIT product.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BKrqnE

Interferon-lambda1 enhances Staphylococcus aureus clearance in healthy nasal mucosa, not in nasal polyps

IFN-λ1 has anti-bacterial activity, and favors the clearance of S. aureus in human nasal mucosa of healthy subjects by various mechanisms, which do not work in nasal polyposis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KJNOAs

Multiple calcifying hyperplastic dental follicles: a case report

Multiple calcifying hyperplastic dental follicles (MCHDF) is a rare condition of calcification in follicles of multiple impacted teeth. Radiologically it appears as multiple pericoronal radiolucencies with radiopaque foci. This report presents a case of MCHDF in a 22-year-old male.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DSxk7H

Multiple calcifying hyperplastic dental follicles: a case report

Multiple calcifying hyperplastic dental follicles (MCHDF) is a rare condition of calcification in follicles of multiple impacted teeth. Radiologically it appears as multiple pericoronal radiolucencies with radiopaque foci. This report presents a case of MCHDF in a 22-year-old male.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DSxk7H

Buccinator and Mandibular Node Metastases in Oral Squamous Cell Carcinoma

The buccinator and mandibular nodes both belong to the facial lymph node group, and metastasis of oral cancer to these nodes is extremely rare. The purpose of this study was to indicate the particular rare metastasis cases wherein we administered treatment for the buccinator or mandibular nodes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QrgWBJ

Buccinator and Mandibular Node Metastases in Oral Squamous Cell Carcinoma

The buccinator and mandibular nodes both belong to the facial lymph node group, and metastasis of oral cancer to these nodes is extremely rare. The purpose of this study was to indicate the particular rare metastasis cases wherein we administered treatment for the buccinator or mandibular nodes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QrgWBJ

Commentary: Propofol Versus Remifentanil: Which One Is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial

We recently read the article by Eshghpour et al., "Propofol versus Remifentanil: Which One is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial."1 As a center that performs a high volume of orthognathic surgical procedures annually, we were very interested in this work as it purports to present high-level evidence for minimizing blood loss during these operations. However, upon critically evaluating the work, we identified several issues that may preclude acceptance of the authors' stated conclusions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DVpFFx

Commentary: Propofol Versus Remifentanil: Which One Is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial

We recently read the article by Eshghpour et al., "Propofol versus Remifentanil: Which One is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial."1 As a center that performs a high volume of orthognathic surgical procedures annually, we were very interested in this work as it purports to present high-level evidence for minimizing blood loss during these operations. However, upon critically evaluating the work, we identified several issues that may preclude acceptance of the authors' stated conclusions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DVpFFx

Industry payments in oral and maxillofacial surgery: a review of 112,478 payments from a national disclosure program

The purpose of this study was to characterize the sources, amounts, and nature of general industry payments to oral and maxillofacial surgeons (OMSs).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qq6niy

Industry payments in oral and maxillofacial surgery: a review of 112,478 payments from a national disclosure program

The purpose of this study was to characterize the sources, amounts, and nature of general industry payments to oral and maxillofacial surgeons (OMSs).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qq6niy

Foreign bodies in the ear, nose, and throat in Japan: association with sociocultural and geographical conditions

Foreign bodies (FBs) in ear, nose, and throat (ENT) are common ENT emergencies but are sometimes life-threatening. However, FBs could be avoidable by the efficient announcement about the risk of these occurrence to the public. Fish bones are commonly found as throat FBs, and small toys are commonly found as pediatric ear and nose FBs. We hypothesized that there were relationships between the occurrence of FBs and sociocultural/geographical conditions. The purpose of this study is to clarify the risk factors of FBs in ENT regions related to eating customs and weather conditions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QqiM5Y

Foreign bodies in the ear, nose, and throat in Japan: association with sociocultural and geographical conditions

Foreign bodies (FBs) in ear, nose, and throat (ENT) are common ENT emergencies but are sometimes life-threatening. However, FBs could be avoidable by the efficient announcement about the risk of these occurrence to the public. Fish bones are commonly found as throat FBs, and small toys are commonly found as pediatric ear and nose FBs. We hypothesized that there were relationships between the occurrence of FBs and sociocultural/geographical conditions. The purpose of this study is to clarify the risk factors of FBs in ENT regions related to eating customs and weather conditions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QqiM5Y

A Deep Learning-Based Approach for the Detection and Localization of Prostate Cancer in T2 Magnetic Resonance Images

Abstract

We address the problem of prostate lesion detection, localization, and segmentation in T2W magnetic resonance (MR) images. We train a deep convolutional encoder-decoder architecture to simultaneously segment the prostate, its anatomical structure, and the malignant lesions. To incorporate the 3D contextual spatial information provided by the MRI series, we propose a novel 3D sliding window approach, which preserves the 2D domain complexity while exploiting 3D information. Experiments on data from 19 patients provided for the public by the Initiative for Collaborative Computer Vision Benchmarking (I2CVB) show that our approach outperforms traditional pattern recognition and machine learning approaches by a significant margin. Particularly, for the task of cancer detection and localization, the system achieves an average AUC of 0.995, an accuracy of 0.894, and a recall of 0.928. The proposed mono-modal deep learning-based system performs comparably to other multi-modal MR-based systems. It could improve the performance of a radiologist in prostate cancer diagnosis and treatment planning.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U2pWMP

A Deep Learning-Based Approach for the Detection and Localization of Prostate Cancer in T2 Magnetic Resonance Images

Abstract

We address the problem of prostate lesion detection, localization, and segmentation in T2W magnetic resonance (MR) images. We train a deep convolutional encoder-decoder architecture to simultaneously segment the prostate, its anatomical structure, and the malignant lesions. To incorporate the 3D contextual spatial information provided by the MRI series, we propose a novel 3D sliding window approach, which preserves the 2D domain complexity while exploiting 3D information. Experiments on data from 19 patients provided for the public by the Initiative for Collaborative Computer Vision Benchmarking (I2CVB) show that our approach outperforms traditional pattern recognition and machine learning approaches by a significant margin. Particularly, for the task of cancer detection and localization, the system achieves an average AUC of 0.995, an accuracy of 0.894, and a recall of 0.928. The proposed mono-modal deep learning-based system performs comparably to other multi-modal MR-based systems. It could improve the performance of a radiologist in prostate cancer diagnosis and treatment planning.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2U2pWMP

In Response to Accuracy and Reliability of the Flow Coupler in Postoperative Monitoring of Head and Neck Free Flaps

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DTr1Rd

In Response to Accuracy and Reliability of the Flow Coupler in Postoperative Monitoring of Head and Neck Free Flaps

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DTr1Rd

IFAR 2018 Reviewers

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E8AhlJ

Changes in the clinical and histological characteristics of Chinese chronic rhinosinusitis with nasal polyps over 11 years

Background

Traditionally, it was believed that chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrated less eosinophilic and more neutrophilic inflammation in China compared to North America and Europe. However, inflammatory patterns may change over time. The study aimed to analyze the changing trends in the clinical and histological characteristics of CRSwNP over time in China.

Methods

A total of 115 consecutive CRSwNP patients from 2003 to 2005 and 114 consecutive CRSwNP patients from 2014 to 2016 were enrolled in this retrospective study. The clinical and histological data were compared between patients from the 2 time periods.

Results

The percentage of eosinophils in nasal polyp tissue increased, and the percentage of neutrophils and total inflammatory cell count decreased, over 11 years. The proportion of eosinophilic CRSwNP significantly increased from 59.1% to 73.7% over 11 years. The proportion of neutrophils and the total inflammatory cell count in nasal polyps decreased, and the proportion of eosinophilic CRSwNP patients using intranasal corticosteroids 1 month before surgery increased remarkably over 11 years. Moreover, eosinophilic CRSwNP patients had better compliance with intranasal corticosteroid use than non‐eosinophilic CRSwNP patients, and patients with comorbid allergic rhinitis and asthma had better compliance with intranasal corticosteroid use than patients without those conditions.

Conclusion

Eosinophilic CRSwNP, which was previously a minor subtype in East Asians, has increased remarkably in incidence to become the predominant CRSwNP subtype in Beijing, China, indicating that rhinologists should place greater emphasis on its diagnosis and treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SkgySU

IFAR 2018 Reviewers

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E8AhlJ

Changes in the clinical and histological characteristics of Chinese chronic rhinosinusitis with nasal polyps over 11 years

Background

Traditionally, it was believed that chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrated less eosinophilic and more neutrophilic inflammation in China compared to North America and Europe. However, inflammatory patterns may change over time. The study aimed to analyze the changing trends in the clinical and histological characteristics of CRSwNP over time in China.

Methods

A total of 115 consecutive CRSwNP patients from 2003 to 2005 and 114 consecutive CRSwNP patients from 2014 to 2016 were enrolled in this retrospective study. The clinical and histological data were compared between patients from the 2 time periods.

Results

The percentage of eosinophils in nasal polyp tissue increased, and the percentage of neutrophils and total inflammatory cell count decreased, over 11 years. The proportion of eosinophilic CRSwNP significantly increased from 59.1% to 73.7% over 11 years. The proportion of neutrophils and the total inflammatory cell count in nasal polyps decreased, and the proportion of eosinophilic CRSwNP patients using intranasal corticosteroids 1 month before surgery increased remarkably over 11 years. Moreover, eosinophilic CRSwNP patients had better compliance with intranasal corticosteroid use than non‐eosinophilic CRSwNP patients, and patients with comorbid allergic rhinitis and asthma had better compliance with intranasal corticosteroid use than patients without those conditions.

Conclusion

Eosinophilic CRSwNP, which was previously a minor subtype in East Asians, has increased remarkably in incidence to become the predominant CRSwNP subtype in Beijing, China, indicating that rhinologists should place greater emphasis on its diagnosis and treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SkgySU

Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Condition:   Conductive Hearing Loss Interventions:   Device: Adhear;   Device: Contact Mini (CM) Sponsor:   Dominik Riss Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E6QSGy

Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Condition:   Conductive Hearing Loss Interventions:   Device: Adhear;   Device: Contact Mini (CM) Sponsor:   Dominik Riss Recruiting (Source: ClinicalTrials.gov)

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CUSUM charts in the quality control of colon cancer lymph node analysis: a population-registry study

The most important determinant of survival in patients with colon cancer is the presence or absence of regional lymph node metastases. This factor is consistently associated with long-term and disease-specific...

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CUSUM charts in the quality control of colon cancer lymph node analysis: a population-registry study

The most important determinant of survival in patients with colon cancer is the presence or absence of regional lymph node metastases. This factor is consistently associated with long-term and disease-specific...

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Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure

Condition:   HIV Infections Interventions:   Biological: a1DC + inactivated whole autologous HIV;   Biological: a1DC + conserved HIV peptides;   Biological: a1DC + no antigen;   Biological: pgDC + inactivated whole autologous HIV;   Biological: pgDC + conserved HIV peptides;   Biological: pgDC + no antigen Sponsors:   Sharon Riddler;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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A Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut After Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine

Condition:   Peanut Allergy Interventions:   Drug: ASP0892;   Drug: Placebo Sponsor:   Astellas Pharma Global Development, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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Demonstration of Equivalent Effectiveness of a Novel Anti-allergic Nasal Spray and a Marketed Nasal Product as Well as Demonstration of Fast Symptom Reduction in Allergic Patients

Conditions:   Allergic Rhinitis;   Allergic Conjunctivitis;   Hayfever Interventions:   Drug: Rhinocort;   Drug: Budesolv;   Other: Placebo Sponsor:   Marinomed Biotech AG Enrolling by invitation (Source: ClinicalTrials.gov)

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Amoxicillin Challenge for Penicillin Allergy Diagnosis

Condition:   Penicillin Allergy Intervention:   Diagnostic Test: Penicillin Skin Testing Sponsor:   CHU de Quebec-Universite Laval Not yet recruiting (Source: ClinicalTrials.gov)

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BPF Genetics of ILD Study

Conditions:   Lung; Disease, Interstitial, With Fibrosis;   Alveolitis, Extrinsic Allergic;   Bird Fancier's Lung;   Idiopathic Interstitial Pneumonias;   Lung Diseases, Interstitial;   Idiopathic Pulmonary Fibrosis Intervention:   Diagnostic Test: Genetic profiling Sponsors:   NHS Forth Valley;   University of Leicester;   University of Glasgow;   Newcastle University;   British Lung Foundation;   British Pigeon Fanciers Medical Research Not yet recruiting (Source: ClinicalTrials.gov)

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N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France

Conditions:   Allergic Rhinitis Due to House Dust Mite;   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus Intervention:   Drug: Tablet, Dispersible Sponsors:   ALK-Abelló A/S;   ITEC Services Recruiting (Source: ClinicalTrials.gov)

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Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure

Condition:   HIV Infections Interventions:   Biological: a1DC + inactivated whole autologous HIV;   Biological: a1DC + conserved HIV peptides;   Biological: a1DC + no antigen;   Biological: pgDC + inactivated whole autologous HIV;   Biological: pgDC + conserved HIV peptides;   Biological: pgDC + no antigen Sponsors:   Sharon Riddler;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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A Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut After Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine

Condition:   Peanut Allergy Interventions:   Drug: ASP0892;   Drug: Placebo Sponsor:   Astellas Pharma Global Development, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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Demonstration of Equivalent Effectiveness of a Novel Anti-allergic Nasal Spray and a Marketed Nasal Product as Well as Demonstration of Fast Symptom Reduction in Allergic Patients

Conditions:   Allergic Rhinitis;   Allergic Conjunctivitis;   Hayfever Interventions:   Drug: Rhinocort;   Drug: Budesolv;   Other: Placebo Sponsor:   Marinomed Biotech AG Enrolling by invitation (Source: ClinicalTrials.gov)

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Amoxicillin Challenge for Penicillin Allergy Diagnosis

Condition:   Penicillin Allergy Intervention:   Diagnostic Test: Penicillin Skin Testing Sponsor:   CHU de Quebec-Universite Laval Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zAiuQt

BPF Genetics of ILD Study

Conditions:   Lung; Disease, Interstitial, With Fibrosis;   Alveolitis, Extrinsic Allergic;   Bird Fancier's Lung;   Idiopathic Interstitial Pneumonias;   Lung Diseases, Interstitial;   Idiopathic Pulmonary Fibrosis Intervention:   Diagnostic Test: Genetic profiling Sponsors:   NHS Forth Valley;   University of Leicester;   University of Glasgow;   Newcastle University;   British Lung Foundation;   British Pigeon Fanciers Medical Research Not yet recruiting (Source: ClinicalTrials.gov)

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N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France

Conditions:   Allergic Rhinitis Due to House Dust Mite;   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus Intervention:   Drug: Tablet, Dispersible Sponsors:   ALK-Abelló A/S;   ITEC Services Recruiting (Source: ClinicalTrials.gov)

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A novel use of intratympanic dexamethasone for intractable posterior canal benign paroxysmal positional vertigo: report of two cases.

Related Articles

A novel use of intratympanic dexamethasone for intractable posterior canal benign paroxysmal positional vertigo: report of two cases.

J Laryngol Otol. 2018 Nov 29;:1-3

Authors: Kelkar A, Johnson I

Abstract
BACKGROUND: Benign paroxysmal positional vertigo is a common inner-ear pathology, characterised by episodic vertigo lasting for a few seconds that is associated with sudden change in the head position. Benign paroxysmal positional vertigo is treated with canalolith repositioning manoeuvres. Intractable vertigo describes a small group of patients who either do not improve with canalolith repositioning manoeuvres (persistent cases) or who relapse after improvement of initial symptoms (recurrent cases). These cases are difficult to treat and may have to be treated surgically.Case reportsThis paper reports two cases of intractable posterior canal benign paroxysmal positional vertigo that were treated with intratympanic dexamethasone injections on an interval basis.
RESULTS: Both patients showed good control of their vertiginous symptoms, with negative Dix-Hallpike test findings following the intervention.
CONCLUSION: The findings support an underlying inflammatory pathology in intractable benign paroxysmal positional vertigo; intratympanic steroids should be considered as an intermediate option before proceeding to a definitive surgical intervention.

PMID: 30486912 [PubMed - as supplied by publisher]

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Challenges in diffusion MRI tractography – Lessons learned from international benchmark competitions

Publication date: Available online 29 November 2018

Source: Magnetic Resonance Imaging

Author(s): Kurt G. Schilling, Alessandro Daducci, Klaus Maier-Hein, Cyril Poupon, Jean-Christophe Houde, Vishwesh Nath, Adam W. Anderson, Bennett A. Landman, Maxime Descoteaux

Abstract

Diffusion MRI (dMRI) fiber tractography has become a pillar of the neuroimaging community due to its ability to noninvasively map the structural connectivity of the brain. Despite widespread use in clinical and research domains, these methods suffer from several potential drawbacks or limitations. Thus, validating the accuracy and reproducibility of techniques is critical for sound scientific conclusions and effective clinical outcomes. Towards this end, a number of international benchmark competitions, or "challenges", has been organized by the diffusion MRI community in order to investigate the reliability of the tractography process by providing a platform to compare algorithms and results in a fair manner, and evaluate common and emerging algorithms in an effort to advance the state of the field. In this paper, we summarize the lessons from a decade of challenges in tractography, and give perspective on the past, present, and future "challenges" that the field of diffusion tractography faces.

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A novel use of intratympanic dexamethasone for intractable posterior canal benign paroxysmal positional vertigo: report of two cases.

Related Articles

A novel use of intratympanic dexamethasone for intractable posterior canal benign paroxysmal positional vertigo: report of two cases.

J Laryngol Otol. 2018 Nov 29;:1-3

Authors: Kelkar A, Johnson I

Abstract
BACKGROUND: Benign paroxysmal positional vertigo is a common inner-ear pathology, characterised by episodic vertigo lasting for a few seconds that is associated with sudden change in the head position. Benign paroxysmal positional vertigo is treated with canalolith repositioning manoeuvres. Intractable vertigo describes a small group of patients who either do not improve with canalolith repositioning manoeuvres (persistent cases) or who relapse after improvement of initial symptoms (recurrent cases). These cases are difficult to treat and may have to be treated surgically.Case reportsThis paper reports two cases of intractable posterior canal benign paroxysmal positional vertigo that were treated with intratympanic dexamethasone injections on an interval basis.
RESULTS: Both patients showed good control of their vertiginous symptoms, with negative Dix-Hallpike test findings following the intervention.
CONCLUSION: The findings support an underlying inflammatory pathology in intractable benign paroxysmal positional vertigo; intratympanic steroids should be considered as an intermediate option before proceeding to a definitive surgical intervention.

PMID: 30486912 [PubMed - as supplied by publisher]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FQKlkV

Challenges in diffusion MRI tractography – Lessons learned from international benchmark competitions

Publication date: Available online 29 November 2018

Source: Magnetic Resonance Imaging

Author(s): Kurt G. Schilling, Alessandro Daducci, Klaus Maier-Hein, Cyril Poupon, Jean-Christophe Houde, Vishwesh Nath, Adam W. Anderson, Bennett A. Landman, Maxime Descoteaux

Abstract

Diffusion MRI (dMRI) fiber tractography has become a pillar of the neuroimaging community due to its ability to noninvasively map the structural connectivity of the brain. Despite widespread use in clinical and research domains, these methods suffer from several potential drawbacks or limitations. Thus, validating the accuracy and reproducibility of techniques is critical for sound scientific conclusions and effective clinical outcomes. Towards this end, a number of international benchmark competitions, or "challenges", has been organized by the diffusion MRI community in order to investigate the reliability of the tractography process by providing a platform to compare algorithms and results in a fair manner, and evaluate common and emerging algorithms in an effort to advance the state of the field. In this paper, we summarize the lessons from a decade of challenges in tractography, and give perspective on the past, present, and future "challenges" that the field of diffusion tractography faces.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SjNuuQ

Micro ad-hoc health social networks (uhsn). Design and evaluation of a social-based solution for patient support

We describe the proposed methods for evaluating the uHSN quantitatively and qualitatively, and how the scientific community can replicate and/or integrate this contribution in its research.ResultsThe uHSN overcomes the main limitations of traditional HSNs in the main areas recommended in the literature: privacy, security, transparency, system ecology, Quality of Service (QoS), and technology enhancement. The qualitative and quantitative research demonstrated its viability and replicability in four key points: user acceptance, productivity improvement, QoS enhancement, and fostering of social relations. It also meets the expectation of connecting health and social worlds, supporting distance rehabilitation, improving professionals' efficiency, expanding users' social capital, improving ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rp8wbv

Micro ad-hoc health social networks (uhsn). Design and evaluation of a social-based solution for patient support

We describe the proposed methods for evaluating the uHSN quantitatively and qualitatively, and how the scientific community can replicate and/or integrate this contribution in its research.ResultsThe uHSN overcomes the main limitations of traditional HSNs in the main areas recommended in the literature: privacy, security, transparency, system ecology, Quality of Service (QoS), and technology enhancement. The qualitative and quantitative research demonstrated its viability and replicability in four key points: user acceptance, productivity improvement, QoS enhancement, and fostering of social relations. It also meets the expectation of connecting health and social worlds, supporting distance rehabilitation, improving professionals' efficiency, expanding users' social capital, improving ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Exploring patterns of alcohol misuse in treatment-seeking UK veterans: A cross-sectional study

Publication date: Available online 29 November 2018

Source: Addictive Behaviors

Author(s): Dominic Murphy, David Turgoose

Abstract

Aims

To explore patterns of alcohol misuse in a sample of treatment-seeking veterans compared to the UK Armed Forces personnel population and the general public. Furthermore, the present study investigated which variables were associated with alcohol misuse in this sample, and in particular what factors were associated with increased or decreased severity of alcohol misuse.

Method

The present study investigated alcohol misuse in treatment-seeking veterans and compared it with the UK Armed Forces and the general public. In addition, it explored associations between sociodemographic, physical health and mental health variables and alcohol misuse.

Results

Results suggested that treatment-seeking veterans report different patterns of alcohol misuse compared to the UK Armed Forces and the general public. This group was more likely to report alcohol dependence and alcohol-related harm. They also reported higher levels of overall alcohol misuse than the general public. Mental health problems including PTSD, anxiety and depression, as well as anger, functional impairment and being single were all related to greater alcohol misuse. Being older and not in work were related to reduced alcohol misuse.

Conclusions

These findings add further weight to the importance of ensuring appropriate support is provided to personnel leaving the Armed Forces. Treatment-seeking veterans have specific patterns of alcohol-related needs that should be addressed. Knowing more about the common alcohol-related problems in this group can help inform and improve mental health interventions. Findings on related variables will help in identifying those individuals who may be at most risk of alcohol-related problems.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RpMvcz

Exploring patterns of alcohol misuse in treatment-seeking UK veterans: A cross-sectional study

Publication date: Available online 29 November 2018

Source: Addictive Behaviors

Author(s): Dominic Murphy, David Turgoose

Abstract

Aims

To explore patterns of alcohol misuse in a sample of treatment-seeking veterans compared to the UK Armed Forces personnel population and the general public. Furthermore, the present study investigated which variables were associated with alcohol misuse in this sample, and in particular what factors were associated with increased or decreased severity of alcohol misuse.

Method

The present study investigated alcohol misuse in treatment-seeking veterans and compared it with the UK Armed Forces and the general public. In addition, it explored associations between sociodemographic, physical health and mental health variables and alcohol misuse.

Results

Results suggested that treatment-seeking veterans report different patterns of alcohol misuse compared to the UK Armed Forces and the general public. This group was more likely to report alcohol dependence and alcohol-related harm. They also reported higher levels of overall alcohol misuse than the general public. Mental health problems including PTSD, anxiety and depression, as well as anger, functional impairment and being single were all related to greater alcohol misuse. Being older and not in work were related to reduced alcohol misuse.

Conclusions

These findings add further weight to the importance of ensuring appropriate support is provided to personnel leaving the Armed Forces. Treatment-seeking veterans have specific patterns of alcohol-related needs that should be addressed. Knowing more about the common alcohol-related problems in this group can help inform and improve mental health interventions. Findings on related variables will help in identifying those individuals who may be at most risk of alcohol-related problems.

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Histologic Improvements in Irradiated Bone Through Pharmaceutical Intervention in Mandibular Distraction Osteogenesis

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Kevin M. Urlaub, Jeremy V. Lynn, Edward G. Carey, Noah S. Nelson, Yekaterina Polyatskaya, Alexis Donneys, Amanda C. Mazzoli, Steven R. Buchman

Purpose

Despite the relative surgical ease and reduced donor-site morbidity of distraction osteogenesis (DO) in comparison with free tissue transfer, DO is currently precluded as a reconstructive option for head and neck cancer (HNC) patients because of the destructive effects of radiotherapy (XRT). This study investigates the ability of a novel combined therapy (CT) of radioprotective amifostine (AMF) and angiogenic deferoxamine (DFO) to mitigate XRT-induced bone injury in a murine model of DO.

Materials and Methods

Thirty male Sprague-Dawley rats were divided into 5 groups: DO (primary control), XRT (secondary control), AMF, DFO, and CT. With the exclusion of the DO group, all rats were administered a fractionated, human-equivalent XRT dose of 35 Gy, comparable with 70 Gy administered to HNC patients clinically. All groups underwent mandibular osteotomy and distraction to 5.1 mm. After euthanasia administration on postoperative day 40, the mandibles were sectioned and stained with Gomori trichrome. Osteocyte number, bone volume, and osteoid volume were compared between all groups by analysis of variance (P < .05).

Results

All rats survived and were included in the final analysis. The XRT group exhibited substantial bone injury, evidenced by a decreased osteocyte number and bone volume, as well as an increase in immature osteoid volume, compared with DO controls. The AMF, DFO, and CT groups showed significant increases in osteocyte proliferation compared with the XRT group and were not statistically different from the DO group. Notably, the CT group showed remediation of XRT-induced impairment of bone maturation and exhibited significantly greater bone volume and reduced osteoid volume in comparison with all groups.

Conclusions

Combined AMF and DFO treatment showed the capacity to remediate the deleterious effects of XRT, restore cellularity to nonirradiated levels, and surpass all groups in mature bone formation. Although further investigations of AMF and DFO are warranted, this study provides preliminary support for the potential use of DO in HNC patients through pharmaceutical facilitation of irradiated bone healing.

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A History of Orthognathic Surgery in North America

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): R. Bryan Bell

This review highlights the contributions of American oral and maxillofacial surgeons to the field of orthognathic surgery. The present state of the art and science of orthognathic surgery is the harvest of yesterday's innovation and research. An improved understanding of the biological and surgical principles and the routine involvement of orthodontics have fueled widespread adoption of a coordinated approach to the treatment of dentofacial problems. Technologic advances in rigid internal fixation, virtual surgical planning with computer-aided manufacturing of occlusal splints and cutting guides, custom implants, and worldwide interest in the correction of dentofacial and craniofacial deformities have resulted in highly predictable, efficient, and safe treatment, which scarcely resembles the situation 70 years ago.

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Is There a Difference in Orbital Volume Between Affected and Unaffected Sides in Patients With Unilateral Craniofacial Microsomia?

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Maria N. Gribova, Britt I. Pluijmers, Cory M. Resnick, Cornelia J.J.M. Caron, Alessandro Borghi, Maarten J. Koudstaal, Bonnie L. Padwa

Purpose

Craniofacial microsomia (CFM) is characterized by malformations of structures derived from the first and second pharyngeal arches. The orbit is variably affected. The purpose of this study was to determine whether there is a difference in orbital volume between affected and unaffected sides in patients with unilateral CFM. The specific aims were to 1) measure orbital volume, 2) compare affected and unaffected sides, 3) evaluate the correlation between clinical evaluation of orbital size and volumetric measurement, and 4) determine whether there is a correlation between orbital volume and severity of mandibular deformity.

Materials and Methods

This study is a retrospective case series of patients with unilateral CFM from Boston Children's Hospital (Boston, MA) who had a computed tomographic (CT) scan. Manual segmentation of the orbit using Mimics software (Materialise, Leuven, Belgium) was performed on CT images of the 2 orbits. The predictor variable was laterality (affected vs unaffected side) and the primary outcome variable was orbital volume. Wilcoxon signed rank test was used to compare these measurements and determine whether the affected side differed from the unaffected side. The correlation between orbital volume and Pruzansky-Kaban type of mandibular deformity, as documented in the medical record, was determined using the Spearman rank correlation coefficient.

Results

Thirty-nine patients were included. Orbital volume was 10% smaller on the affected side (P = .001) in 80% of patients. There was no correlation between orbital size and severity of mandibular involvement.

Conclusion

The results of this study showed a marked difference in orbital volume between affected and unaffected sides in patients with unilateral CFM. These differences were small and might not be clinically relevant. Orbital volume did not correlate with severity of mandibular deformity.

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Surgical Accuracy in Inferior Maxillary Reposition

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Kasper Stokbro, Torben Thygesen

Purpose

Inferior maxillary repositioning is among the least stable and least predictable orthognathic procedures. The purpose of this study was to investigate whether posterior movement occurred with inferior maxillary repositioning and to analyze potential causes.

Materials and Methods

This retrospective observational study evaluated all consecutive patients treated at the Department of Oral and Maxillofacial Surgery of the Odense University Hospital (Odense, Denmark) with inferior maxillary repositioning from 2011 to 2013. The obtained repositioning was compared with the virtual surgical plan to determine surgical accuracy. Measurements were performed at 3 dental reference points. Linear and rotational measurements were performed along and around the right, anterior, and superior axes. Measurements were compared by paired t tests. Internal correlations and confounding variables were analyzed by mixed model regression analysis.

Results

Twenty patients were included for analysis. On average, the maxilla was positioned 1 mm posterior and 0.4 mm superior to the planned position. The virtual surgically planned reposition was statistically correlated with surgical accuracy. No other confounding variable influenced the outcome.

Conclusion

The correlation between planned advancement and inferior repositioning suggests that inferior repositioning destabilizes the maxillary position and that a perioperative or early postoperative relapse occurs in response to the advancement. This immediate relapse of 1 mm should be considered in the virtual surgical plan to ensure that the maxilla is placed closer to the desired position. Thus, this procedure could still benefit from increased surgical precision and stability based on technologic advancements, such as positioning guides or printed patient-specific plates.

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Use of Nasal Conformer After Birth Effectively Improves Nostril Symmetry in Patients With Unilateral Incomplete Cleft Lip

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Spencer C.H. Kuo, Jui-Pin Lai, Ching-Hua Hsieh, Tzu-Ying Chen, Yu-Jen Chang, Faye Huang

Purpose

To investigate the clinical effects of preoperative nasoalveolar molding (NAM) and nasal conformer use in patients with unilateral incomplete cleft lip on the basis of their medical records and images.

Patients and Methods

Data and images of 16 patients born with unilateral incomplete cleft lip who were hospitalized between January 2015 and August 2017 were retrieved from the medical records. The primary outcome was the extent of improvement in columella height (CH) before cheiloplasty. Other outcome measurements included the CH, nostril width, and nostril height, which were measured by ImageJ image processing software (version 1.4; National Institutes of Health, Bethesda, MD) and presented as ratios. Mann-Whitney U tests were used to compare the non–normally distributed data.

Results

Patients in the NAM group and those in the nasal conformer group showed significantly improved (P < .05) preoperative cleft-side CH–to–normal-side CH ratios compared with the corresponding ratios at birth. There was no significant difference in terms of the extent of improvement in CH between the groups.

Conclusions

Preoperative use of nasal conformers in patients with unilateral incomplete cleft lip not only corrects the deformed nasal cartilage but also increases the CH and improves the overall preoperative nasal symmetry. In addition, compared with NAM, this method costs less, is more straightforward, and requires fewer outpatient clinic visits.

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Histologic Improvements in Irradiated Bone Through Pharmaceutical Intervention in Mandibular Distraction Osteogenesis

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Kevin M. Urlaub, Jeremy V. Lynn, Edward G. Carey, Noah S. Nelson, Yekaterina Polyatskaya, Alexis Donneys, Amanda C. Mazzoli, Steven R. Buchman

Purpose

Despite the relative surgical ease and reduced donor-site morbidity of distraction osteogenesis (DO) in comparison with free tissue transfer, DO is currently precluded as a reconstructive option for head and neck cancer (HNC) patients because of the destructive effects of radiotherapy (XRT). This study investigates the ability of a novel combined therapy (CT) of radioprotective amifostine (AMF) and angiogenic deferoxamine (DFO) to mitigate XRT-induced bone injury in a murine model of DO.

Materials and Methods

Thirty male Sprague-Dawley rats were divided into 5 groups: DO (primary control), XRT (secondary control), AMF, DFO, and CT. With the exclusion of the DO group, all rats were administered a fractionated, human-equivalent XRT dose of 35 Gy, comparable with 70 Gy administered to HNC patients clinically. All groups underwent mandibular osteotomy and distraction to 5.1 mm. After euthanasia administration on postoperative day 40, the mandibles were sectioned and stained with Gomori trichrome. Osteocyte number, bone volume, and osteoid volume were compared between all groups by analysis of variance (P < .05).

Results

All rats survived and were included in the final analysis. The XRT group exhibited substantial bone injury, evidenced by a decreased osteocyte number and bone volume, as well as an increase in immature osteoid volume, compared with DO controls. The AMF, DFO, and CT groups showed significant increases in osteocyte proliferation compared with the XRT group and were not statistically different from the DO group. Notably, the CT group showed remediation of XRT-induced impairment of bone maturation and exhibited significantly greater bone volume and reduced osteoid volume in comparison with all groups.

Conclusions

Combined AMF and DFO treatment showed the capacity to remediate the deleterious effects of XRT, restore cellularity to nonirradiated levels, and surpass all groups in mature bone formation. Although further investigations of AMF and DFO are warranted, this study provides preliminary support for the potential use of DO in HNC patients through pharmaceutical facilitation of irradiated bone healing.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ztXL0s

Is There a Difference in Orbital Volume Between Affected and Unaffected Sides in Patients With Unilateral Craniofacial Microsomia?

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Maria N. Gribova, Britt I. Pluijmers, Cory M. Resnick, Cornelia J.J.M. Caron, Alessandro Borghi, Maarten J. Koudstaal, Bonnie L. Padwa

Purpose

Craniofacial microsomia (CFM) is characterized by malformations of structures derived from the first and second pharyngeal arches. The orbit is variably affected. The purpose of this study was to determine whether there is a difference in orbital volume between affected and unaffected sides in patients with unilateral CFM. The specific aims were to 1) measure orbital volume, 2) compare affected and unaffected sides, 3) evaluate the correlation between clinical evaluation of orbital size and volumetric measurement, and 4) determine whether there is a correlation between orbital volume and severity of mandibular deformity.

Materials and Methods

This study is a retrospective case series of patients with unilateral CFM from Boston Children's Hospital (Boston, MA) who had a computed tomographic (CT) scan. Manual segmentation of the orbit using Mimics software (Materialise, Leuven, Belgium) was performed on CT images of the 2 orbits. The predictor variable was laterality (affected vs unaffected side) and the primary outcome variable was orbital volume. Wilcoxon signed rank test was used to compare these measurements and determine whether the affected side differed from the unaffected side. The correlation between orbital volume and Pruzansky-Kaban type of mandibular deformity, as documented in the medical record, was determined using the Spearman rank correlation coefficient.

Results

Thirty-nine patients were included. Orbital volume was 10% smaller on the affected side (P = .001) in 80% of patients. There was no correlation between orbital size and severity of mandibular involvement.

Conclusion

The results of this study showed a marked difference in orbital volume between affected and unaffected sides in patients with unilateral CFM. These differences were small and might not be clinically relevant. Orbital volume did not correlate with severity of mandibular deformity.

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When Net Loss Threatens Safety Net Loss

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Thomas B. Dodson

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Surgical Accuracy in Inferior Maxillary Reposition

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Kasper Stokbro, Torben Thygesen

Purpose

Inferior maxillary repositioning is among the least stable and least predictable orthognathic procedures. The purpose of this study was to investigate whether posterior movement occurred with inferior maxillary repositioning and to analyze potential causes.

Materials and Methods

This retrospective observational study evaluated all consecutive patients treated at the Department of Oral and Maxillofacial Surgery of the Odense University Hospital (Odense, Denmark) with inferior maxillary repositioning from 2011 to 2013. The obtained repositioning was compared with the virtual surgical plan to determine surgical accuracy. Measurements were performed at 3 dental reference points. Linear and rotational measurements were performed along and around the right, anterior, and superior axes. Measurements were compared by paired t tests. Internal correlations and confounding variables were analyzed by mixed model regression analysis.

Results

Twenty patients were included for analysis. On average, the maxilla was positioned 1 mm posterior and 0.4 mm superior to the planned position. The virtual surgically planned reposition was statistically correlated with surgical accuracy. No other confounding variable influenced the outcome.

Conclusion

The correlation between planned advancement and inferior repositioning suggests that inferior repositioning destabilizes the maxillary position and that a perioperative or early postoperative relapse occurs in response to the advancement. This immediate relapse of 1 mm should be considered in the virtual surgical plan to ensure that the maxilla is placed closer to the desired position. Thus, this procedure could still benefit from increased surgical precision and stability based on technologic advancements, such as positioning guides or printed patient-specific plates.

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AAOMS Author Disclosure forms

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s):

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Use of Nasal Conformer After Birth Effectively Improves Nostril Symmetry in Patients With Unilateral Incomplete Cleft Lip

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s): Spencer C.H. Kuo, Jui-Pin Lai, Ching-Hua Hsieh, Tzu-Ying Chen, Yu-Jen Chang, Faye Huang

Purpose

To investigate the clinical effects of preoperative nasoalveolar molding (NAM) and nasal conformer use in patients with unilateral incomplete cleft lip on the basis of their medical records and images.

Patients and Methods

Data and images of 16 patients born with unilateral incomplete cleft lip who were hospitalized between January 2015 and August 2017 were retrieved from the medical records. The primary outcome was the extent of improvement in columella height (CH) before cheiloplasty. Other outcome measurements included the CH, nostril width, and nostril height, which were measured by ImageJ image processing software (version 1.4; National Institutes of Health, Bethesda, MD) and presented as ratios. Mann-Whitney U tests were used to compare the non–normally distributed data.

Results

Patients in the NAM group and those in the nasal conformer group showed significantly improved (P < .05) preoperative cleft-side CH–to–normal-side CH ratios compared with the corresponding ratios at birth. There was no significant difference in terms of the extent of improvement in CH between the groups.

Conclusions

Preoperative use of nasal conformers in patients with unilateral incomplete cleft lip not only corrects the deformed nasal cartilage but also increases the CH and improves the overall preoperative nasal symmetry. In addition, compared with NAM, this method costs less, is more straightforward, and requires fewer outpatient clinic visits.

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Table of Contents

Publication date: December 2018

Source: Journal of Oral and Maxillofacial Surgery, Volume 76, Issue 12

Author(s):

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