Publication date: Available online 13 November 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Suttiwee Chermprapai, Femke Broere, Yvette M. Schlotter, Edwin J.A. Veldhuizen, Victor P.M.G. RuttenAbstractKeratinocytes (KC) are the main cellular components of the stratum corneum that constitutes a solid physical skin barrier representing the first line of defense against pathogens. Moreover, KC are potent producers of inflammatory mediators and antimicrobial peptides (AMP) when activated through their pattern recognition receptors. In atopic dermatitis (AD) the protective skin barrier may be compromised due to barrier disruption, secondary infection and accelerated secretion of inflammatory cytokines which may also affect AMP expression in the skin. In the present study, we a...
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