Characterization of gene expression profiles and functional analysis of peptidoglycan recognition protein 2 from rock bream (Oplegnathus fasciatus)

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Kwang-Min Choi, Min-Soo Joo, Dong Hee Cho, Jin-Sol Bae, Ji-Min Jung, Jee Youn Hwang, Mun-Gyeong Kwon, Jung Soo Seo, Seong Don Hwang, Bo-Yeong Jee, Do-Hyung Kim, Chan-Il ParkAbstractPeptidoglycan recognition protein 2 (PGRP2) is a Zn2+-dependent peptidase that plays important roles in binding to microbial components of the cell membrane, inducing phagocytosis and antimicrobial activity. Rock bream (Oplegnathus fasciatus) PGRP2 (RbPGRP2) was identified in the intestine by next generation sequencing (NGS) analysis. The open reading frame (ORF) the RbPGRP2 cDNA (470 amino acid residues) contains a peptidoglycan recognition protein domain (residues 300 to 446). Alignment analysis revealed that RbPGRP2 shares ...

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