Dendrobium huoshanense polysaccharide regionally regulates intestinal mucosal barrier function and intestinal microbiota in mice

Publication date: 15 February 2019Source: Carbohydrate Polymers, Volume 206Author(s): Song-Zi Xie, Bing Liu, Hui-Yu Ye, Qiang-Ming Li, Li-Hua Pan, Xue-Qiang Zha, Jian Liu, Jun Duan, Jian-Ping LuoAbstractThe present study investigated the effects of a homogeneous Dendrobium huoshanense polysaccharide (GXG) on mucosal barrier function and microbiota composition in different intestinal regions of mice. Results exhibited, besides changing the intestinal physiological status, orally administrated GXG could improve the intestinal physical barrier function by modulating mucosal structures and up-regulating the expression of tight junction proteins, reinforce the intestinal biochemical barrier function by elevating the expression and secretion of mucin-2, β-defensins and sIgA, and regulate the in...

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