Long ‑term treatment with salicylate enables NMDA receptors and impairs AMPA receptors in C57BL/6J mice inner hair cell ribbon synapse.

Long‑term treatment with salicylate enables NMDA receptors and impairs AMPA receptors in C57BL/6J mice inner hair cell ribbon synapse. Mol Med Rep. 2018 Nov 05;: Authors: Cui W, Wang H, Cheng Y, Ma X, Lei Y, Ruan X, Shi L, Lv M Abstract Salicylate is widely used to produce animal models of tinnitus in mice and/or rats. The side effects on auditory function, including hearing loss and tinnitus, are considered the results of the auditory nerve dysfunction. A recent study indicated that chronic treatment with salicylate for several weeks reduces compressed action potential amplitude, which is contradictory to the studies reporting excessive activation of N‑methyl‑D‑aspartate receptors (NMDAR) in tinnitus‑induced animals. The specific aims of the experiment were ...

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