Mechanisms and functions of IL-17 signaling in renal autoimmune diseases

Publication date: December 2018Source: Molecular Immunology, Volume 104Author(s): Tilman Schmidt, Jonas Luebbe, Hans-Joachim Paust, Ulf PanzerAbstractImmune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4+ T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4+ T cell subset named TH17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Our group and others have shown that the recruitment of TH17 cells to the i...

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