RNF135 is a positive regulator of IFN expression and involved in RIG-I signaling pathway by targeting RIG-I

Publication date: March 2019Source: Fish & Shellfish Immunology, Volume 86Author(s): Yuxiong Lai, Min Liang, La Hu, Zicheng Zeng, Hai Lin, Gao Yi, Ming Li, Zhaoyu LiuAbstractRIG-I-like receptors (RLRs) play a key role in antiviral and inflammatory responses. Increasing evidence indicates that ubiquitination is crucial for regulation of RIG-I signaling pathway. Several ubiquitin ligases were reported to be involved in RIG-I-mediated signal transduction. In the present study, we demonstrated zebrafish RING finger protein 135 (zbRNF135) was a critical player in the regulation of RIG-I signaling pathway. zbRNF135 mRNA was widely expressed in different tissues of zebrafish. The expression of zbRNF135 was up-regulated post poly(I:C) treatment in vivo and in vitro. Furthermore, the expression pro...

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