Aberrant CARD14 function might cause defective barrier formation

We read with great interest the recent report by Peled et  al1 on how loss-of-function mutations in CARD14 (caspase recruitment domain family, member 14) are associated with a severe variant of atopic dermatitis (AD).1 CARD14 encodes a known regulator of nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), and dominant gain-of-function mutations in CARD14 cause psoriasis and related disorders.1,2 Peled et al1 revealed that dominant negative mutations in CARD14 result in severe AD and decreased NF-κB signaling. (Source: Journal of Allergy and Clinical Immunology)

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