Cluster of differentiation 8 T-cell population in the laryngeal mucosa of smokers with laryngeal cancer.

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Cluster of differentiation 8 T-cell population in the laryngeal mucosa of smokers with laryngeal cancer.

J Laryngol Otol. 2018 Dec;132(12):1134-1137

Authors: Elwany S, Radi S, Khalil H, Talaat I, Belasy K

Abstract
OBJECTIVE: To study the cluster of differentiation 8 population in the laryngeal mucosa of patients with laryngeal carcinoma. To our knowledge this is the first paper to address this issue.
METHODS: The study group included 40 patients with known laryngeal cancer who were scheduled for laryngectomy. The control groups included 10 smokers and 10 non-smokers who were scheduled for microlaryngeal surgery. Specimens from the three groups were processed for histopathological and histochemical evaluation.
RESULTS: In patients without cancer of the larynx, the number of cluster of differentiation 8 lymphocytes was greater in smokers than non-smokers. The number of cluster of differentiation 8 lymphocytes was greatest in smokers with laryngeal cancer, and the difference between this group and the two control groups was statistically significant.
CONCLUSION: The study showed that smoking increased the number of cluster of differentiation 8 T-lymphocytes in the laryngeal mucosa. The increase was greatest in patients who had developed laryngeal cancer.

PMID: 30674369 [PubMed - in process]

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