Primary osteosarcoma of the breast: Pathophysiology and Imaging Review

Publication date: Available online 3 January 2019

Source: Current Problems in Diagnostic Radiology

Author(s): Bilal Mujtaba, Sameh M. Nassar, Rizwan Aslam, Naveen Garg, John E. Madewell, Ahmed Taher, Abdelrahman k Hanafy, Gary Whitman

Abstract

Extraskeletal osteosarcoma (ESOS) are rare malignant mesenchymal neoplasms of soft tissues representing around 1% of all soft tissue. The exact mechanism of tumorigenesis of primary breast osteosarcoma still unclear. However, most of the cases develop without a recognized aetiologic factor. Primary osteosarcoma of the breast is often initially misdiagnosed as breast fibroadenoma. Different imaging modalities and pathology play important role in differentiating breast osteosarcoma from other benign and malignant lesions of the breast resulting in dramatic change in the management.

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