Publication date: Available online 3 January 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Francesca Cencetti, Caterina Bernacchioni, Marina Bruno, Roberta Squecco, Eglantina Idrizaj, Matteo Berbeglia, Paola Bruni, Chiara DonatiAbstractHearing loss is among the most prevalent sensory impairments in humans. Cochlear implantable devices represent the current therapies for hearing loss but have various shortcomings. ERM (ezrin, radixin and moesin) are a family of adaptor proteins that link plasma membrane with actin cytoskeleton, playing a crucial role in cell morphology and in the formation of membrane protrusions. Recently, bioactive sphingolipids have emerged as regulators of ERM proteins. Sphingosine 1-phosphate (S1P) is a pleiotropic sphingolipid whi...
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