The Editors' Choice

Atopic dermatitis (AD) and psoriasis are both very common inflammatory skin diseases that show a clear familial predisposition. Familial psoriasis was previously found to result from gain-of-function mutations in CARD14, which encodes the caspase recruitment domain-containing protein 14 (CARD14), a key regulator of NF- κB activity. In this issue, Peled et al (p 173) report that loss-of-function mutations in the same gene are associated with a severe variant of AD. The following are the major clinical implications of this study: (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RtBvxT