Σάββατο 9 Φεβρουαρίου 2019

Cochlear ablation in neonatal rats disrupts inhibitory transmission in the medial nucleus of the trapezoid body

Publication date: Available online 8 February 2019Source: Neuroscience LettersAuthor(s): Bohdana Hruskova, Johana Trojanova, Michaela Kralikova, Adolf Melichar, Stepanka Suchankova, Jolana Bartosova, Jana Svobodova Burianova, Jiri Popelar, Josef Syka, Rostislav TurecekAbstractInhibitory circuits in the auditory brainstem undergo multiple postnatal changes that are both activity-dependent and activity-independent. We tested to see if the shift from GABA- to glycinergic transmission, which occurs in the rat medial nucleus of the trapezoid body (MNTB) around the onset of hearing, depends on sound-evoked neuronal activity. We prevented the activity by bilateral cochlear ablations in early postnatal rats and studied ionotropic GABA and glycine receptors in MNTB neurons after hearing onset. The ...

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