Double-strand break repair through homologous recombination in autosomal-recessive BCL10 deficiency

Three members of the caspase recruitment domain (CARD) family of adaptor proteins (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1), resulting in the CARD-BCL10-MALT1 (CBM) complex. In humans and mice, the CBM complex mediates nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κB) and mitogen-activated protein kinase activation in a cell-type–specific and nonredundant manner, after the stimulation of various immune receptors. (Source: Journal of Allergy and Clinical Immunology)

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