Prognostic Value of the Pretreatment Primary Lesion Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Nasopharyngeal Carcinoma

Publication date: Available online 14 February 2019

Source: Academic Radiology

Author(s): Yuhui Qin, Xiaoping Yu, Jing Hou, Ying Hu, Feiping Li, Lu Wen, Qiang Lu, Siye Liu

Rationale and Objectives

Early identifying the long-term outcome of chemoradiotherapy is helpful for personalized treatment in nasopharyngeal carcinoma (NPC). This study aimed to investigate the prognostic significance of pretreatment quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for NPC.

Materials and Methods

The relationships between the prognosis and pretreatment quantitative DCE-MRI (K^trans, K_ep, V_e, and f_pv) values of the primary tumors were analyzed in 134 NPC patients who received chemoradiotherapy. Kaplan-Meier analysis was performed to calculate the local-regional relapse-free survival (LRRFS), local relapse-free survival (LRFS), regional relapse-free survival, distant metastasis-free survival (DMFS), progression-free survival, and overall survival rates. Cox proportional hazards model was used to explore the independent predictors for prognosis.

Results

The local-failure group had significantly higher V_e (p = 0.033) and f_pv values (p = 0.005) than the non-local-failure group. The V_e-high group showed significantly lower LRRFS (p = 0.015) , LRFS (p = 0.013) , DMFS (p = 0.027) and progression-free survival (p = 0.035) rates than the V_e-low group. The f_pv-high group exhibited significantly lower LRRFS (p = 0.004) and LRFS (p = 0.005) rates than the f_pv-low group. V_e was the independent predictor for LRRFS (p = 0.008), LRFS (p = 0.007), DMFS (p = 0.041), and overall survival (p = 0.022). f_pv was the independent indicator for LRRFS (p = 0.003) and LRFS (p = 0.001).

Conclusion

Baseline quantitative DCE-MRI may be valuable in predicting the prognosis for NPC.

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