Publication date: August 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 8Author(s): Yuan-Yuan GU, Lang SHI, Dan-Dan ZHANG, Xin HUANG, Da-Zhong CHENAbstractShuang-huang-lian Injection (SHLI) is the first successfully developed drug from traditional Chinese medicine (TCM) powder for injection, since its use for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. At the same time, its allergic reactions have also emerged, which limits clinical applications. However, few scholars pay attention to the mechanism of allergic reactions. In this present study, metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction; we and analyzed the metabolites, metabolic pathway, ...
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