Chronic exposure to the ionic liquid [C8mim]Br induces inflammation in silver carp spleen: Involvement of oxidative stress-mediated p38MAPK/NF-κB signalling and microRNAs

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Junguo Ma, Xi Chen, Guangyuan Xin, Xiaoyu LiAbstractThe present study aimed to determine the chronic toxicity of 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on the silver carp to further reveal the toxicological mechanisms of ionic liquids. Chronic exposure of silver carp to [C8mim]Br at concentrations of 1.095 and 4.380 mg/L for 60 d was conducted under laboratory conditions. The results revealed that chronic exposure to [C8mim]Br inhibited the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduced glutathione (GSH) levels while markedly increasing malondialdehyde (MDA) and protein carbonyl (PC) levels in fish spleen, indicating that [C8mim]Br treatm...

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