Coagulopathies and inflammatory diseases:'…glimpse of a Snark'.

Coagulopathies and inflammatory diseases: '…glimpse of a Snark'. Curr Opin Immunol. 2018 Sep 27;55:44-53 Authors: Del Carmen S, Hapak SM, Ghosh S, Rothlin CV Abstract Coagulopathies and inflammatory diseases, ostensibly, have distinct underlying molecular bases. Notwithstanding, both are host defense mechanisms to physical injury. In invertebrates, clotting can function directly in anti-pathogen defense. Molecules of the vertebrate clotting cascade have also been directly linked to the regulation of inflammation. We posit that thrombophilia may provide resistance against pathogens in vertebrates. The selective pressure of improved anti-pathogen defense may have retained mutations associated with a thrombophilic state in the human population and directly contributed t...

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