Cutting Edge: Local Proliferation of Uterine Tissue-Resident NK Cells during Decidualization in Mice.

In this study, we employed a novel, immune-competent NK cell-specific reporter mouse to track accumulation of uNK cells during unmanipulated pregnancies. We identified conventional NK and trNK cells accumulating in both decidua basalis and myometrium. Only trNK cells showed evidence of proliferation. In parabiosis studies using experimentally induced deciduomata, the accumulated uNK cells were proliferating trNK cells; migrating NK cells made no contribution. Together, these data suggest proliferating trNK cells are the source of uNK cells during endometrial decidualization. PMID: 30275046 [PubMed - as supplied by publisher] (Source: Journal of Immunology)

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