Functional characterization of a matrix metalloproteinase 2 gene in Litopenaeus vannamei

Publication date: Available online 11 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Yu-Ying Lian, Hong-Hui He, Chao-Zheng Zhang, Xin-cang Li, Yi-Hong ChenAbstractMatrix metalloproteinases (MMPs) contribute to both normal and pathological tissue remodeling. They act as regulatory molecules by working in enzyme cascades as well as processing matrix proteins, cytokines, growth factors and adhesion molecules to generate fragments with biological effects. So MMPs could play distrinct roles in the process of pathogen infection. In present study, we cloned a MMP-2 (LvMMP-2) gene from Litopenaeus vannamei. LvMMP-2, highly expressed in epidermis, located to endoplasmic reticulum in S2 cells. Results of real-time RT-PCR assay showed that LvMMP-2 was induced in shrimp hemocytes upon unfol...

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