Identification and characterization of a carboxypeptidase N1 from red lip mullet (Liza haematocheila); revealing its immune relevance

Publication date: Available online 6 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): N.C.N. Perera, G.I. Godahewa, Sumi Jung, Myoung-Jin Kim, Bo-Hye Nam, Jehee LeeAbstractComplement system orchestrates the innate and adaptive immunity via the activation, recruitment, and regulation of immune molecules to destroy pathogens. However, regulation of the complement is essential to avoid injuries to the autologous tissues. The present study unveils the characteristic features of an important complement component, anaphylatoxin inactivator from red lip mullet at its molecular and functional level. Mullet carboxypeptidase N1 (MuCPN1) cDNA sequence possessed an open reading frame of 1347 bp, which encoded a protein of 449 amino acids with a predicted molecular weight of 51 kDa. In silic...

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