Role of microRNA-223 in the regulation of poly(ADP-ribose) polymerase in pediatric patients with Crohn's disease.

CONCLUSIONS: In our study, we showed that the expression of miR-223 is up-regulated and poly(ADP-ribosyl)ation is reduced in pediatric patients with CD. Moreover, we confirmed their opposite change in LPS treated epithelial cells, too. These data suggest that the hypofunctionality of PARP-1 may play a potential role in the pathomechanism of CD. PMID: 30299179 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CEJ3Hg