Anxiety and Genetic Polymorphisms in Catecol-O-Metiltransferase (COMT) and Serotonin Transportation Gene (5HTT) Are Associated with Benign Migratory Glossitis

Publication date: Available online 10 November 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Rafaela Scariot, Aline Monise Sebastiani, Michelle Meger, Vinicius Theodoro Broska, Juliana Feltrin Souza, Antonio Adilson Lima, João Armando Brancher, Cleber Machado de Souza, Paulo Henrique Couto Souza, Paula Cristina Trevillato

ABSTRACT

Objective

This case-control study aims to investigate if benign migratory glossitis (BMG) is associated with catechol-O-methyltransferase (COMT) and serotonin transportation gene (5HTT) polymorphisms and anxiety.

Study Design

The study comprised 43 patients with BMG and 114 patients without a history of BMG. We utilized the Hamilton Anxiety Rating Scale (HAM-A) to assess each individual's anxiety. We collected DNA from buccal cells and analysed polymorphisms of COMT and 5HTT. We conducted statistical evaluations using SPSS (IBM, USA) and STATA (StataCorp, USA). Alpha value was set at 0.05.

Results

Overall anxiety level was significantly higher in the case group than in the control group (p < 0.001). In an adjusted multiple logistic regression, the COMT markers were not associated with BMG. Individuals with CC genotype, in rs3813034 of 5HTT, presented an odds ratio of 2.85 (95%CI 1.03 -7.82; p = 0.042). Individuals with TT genotype, in rs1042173 of 5HTT, presented an odds ratio of 3.77 (95%CI 1.32-10.74; p = 0.013). For each incremental increase in anxiety score, there was an 8% increase in the probability of BMG (OR_a=1.08; 95%CI 1.03-1.14; p = 0.007).

Conclusion

Anxiety increases the risk of BMG. Moreover, the occurrence of BMG was associated with polymorphisms in 5HTT gene.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qF40tv