Auditory midbrain hypoplasia and dysmorphology after prenatal valproic acid exposure

Publication date: Available online 17 November 2018Source: NeuroscienceAuthor(s): Yusra Mansour, Sarah Mangold, Devon Chosky, Randy J KuleszaAbstractPrenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans and is used as an animal model of ASD. The majority of individuals with ASD exhibit adverse reactions to sensory stimuli and auditory dysfunction. Previous studies of animals exposed to VPA reveal abnormal neuronal responses to sound and mapping of sound frequency in the cerebral cortex and hyperactivation, hypoplasia and abnormal neuronal morphology in the cochlear nuclei (CN) and superior olivary complex (SOC). Herein, we examine the neuronal populations in the lateral lemniscus and inferior colliculus i...

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