Intermittent Low-level Noise Causes Negative Neural Gain in the Inferior Colliculus

Publication date: Available online 17 November 2018Source: NeuroscienceAuthor(s): Adam Sheppard, Xiaopeng Liu, Anaam Alkharabsheh, Guang-Di Chen, Richard SalviAbstractThe central auditory system shows a remarkable ability to rescale its neural representation of loudness following long-term, low-level acoustic exposures; even when the noise is presented intermittently. Circadian rhythms exert potent biological effects, but it remains unclear if acoustic exposures occurring during the light or dark cycle affect the neurophysiological changes involved in loudness rescaling. To address this issue we exposed rats to intermittent (12 h/day), low-level noise (10-20 kHz, 75 dB SPL) for 5 weeks; exposures occurred during either the light (inactive) or dark (active) phase of the circadian cycle. The...

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