Biofilm Induced Profiles of Immune Response Gene Expression by Oral Epithelial Cells

ConclusionsA wide array of immune genes were regulated by oral bacterial challenge of epithelial cells that would be linked to the local activity of innate and adaptive immune response components in the gingival tissues. Incorporating bacterial species into a structured biofilm dramatically altered the number and level of genes expressed. Additionally a specific set of genes were significantly decreased with the multispecies biofilms suggesting that some epithelial cell biologic pathways are down ‐regulated when in contact with this type of pathogenic biofilm.This article is protected by copyright. All rights reserved. (Source: Molecular Oral Microbiology)

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