Identification of a linear B-cell epitope in the catalytic domain of bothropasin, a metalloproteinase from Bothrops jararaca snake venom

Publication date: December 2018Source: Molecular Immunology, Volume 104Author(s): Denis A. Molina Molina, Clara Guerra-Duarte, Dayane L. Naves de Souza, Fernanda Costal-Oliveira, Giovana Reis de Ávila, Vanete T. Soccol, Ricardo A. Machado-de-Ávila, Carlos Chávez-OlórteguiAbstractBothropasin is a hemorrhagic snake venom metalloproteinase (SVMP) from Bothrops jararaca venom, the snake responsible for most bites in Southeastern Brazil. SVMPs, such as bothropasin, are involved in the main bothropic envenoming symptoms, which include hemorrhage, inflammation, necrosis and blood coagulation deficiency. B-cell epitope mapping of SVMPs can lead to the identification of peptides capable of inducing neutralizing antibodies without causing toxic effects, therefore improving anti-venom production....

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