Preeclampsia: A close look at renal dysfunction

Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Hakimeh Moghaddas Sani, Sepideh Zununi Vahed, Mohammadreza ArdalanAbstractPreeclampsia (PE) is a unique pathophysiologic situation that physiologic interests of mother, fetus, and placenta diverge. PE is related to the increased circulating antiangiogenic factors originated from hypoxic placenta. It is simply defined by the new onset of hypertension (≥140/90 mmHg) and proteinuria (≥0.3 g/day) after 20 weeks of gestation. PE is associated with kidney dysfunction due to deficiency in podocyte specific vascular endothelial growth factor (VEGF). Hypoxic placenta in PE patients produces increased levels of fms-like tyrosine kinase 1(sFlt-1), a soluble receptor of VEGF. sFlt-1 abrogates binding of V...

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