A New Model for Congenital Vestibular Disorders

AbstractMany developmental disorders of the inner ear are manifested clinically as delayed motor development and challenges in maintaining posture and balance, indicating involvement of central vestibular circuits. How the vestibular circuitry is rewired in pediatric cases is poorly understood due to lack of a suitable animal model. Based on this, our lab designed and validated a chick embryo model to study vestibular development in congenital vestibular disorders. The developing inner ear or "otocyst" on the right side of 2-day-old chick embryos (E2) was surgically rotated 180° in the anterior–posterior axis, forming the "anterior–posterior axis rotated otocyst chick" or ARO chick. The ARO chick has areproducible pathology of a sac with truncated or missing semicircular canal...

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