Molecules, Vol. 23, Pages 3196: Pseudane-VII Regulates LPS-Induced Neuroinflammation in Brain Microglia Cells through the Inhibition of iNOS Expression

Authors: Mi Eun Kim Inae Jung Ju Yong Na Yujeong Lee Jaewon Lee Jong Suk Lee Jun Sik Lee We previously isolated pseudane-VII from the secondary metabolites of Pseudoalteromonas sp. M2 in marine water, and demonstrated its anti-inflammatory efficacy on macrophages. However, the molecular mechanism by which pseudane-VII suppresses neuroinflammation has not yet been elucidated in brain microglia. Microglia is activated by immunological stimulation or brain injury. Activated microglia secrete proinflammatory mediators which damage neurons. Neuroinflammation appears to be associated with certain neurological diseases, including Parkinson's disease and Alzheimer's disease. Natural compounds that suppress microglial inflammatory responses could potent...

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