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Basal cell hyperplasia is a fundamental feature of severe allergic inflammatory diseases, including chronic rhinosinusitis, and occurs secondary to enhanced accumulation of epithelial progenitor cells. To clarify the interactions and roles of this enigmatic cellular population in the context of allergic inflammation, Ordovas-Montanes et al (Nature 2018;560:649-54; https://ift.tt/2KZ5xUG) generated genome-wide transcriptional profiles of more than 50,000 individual cells through unbiased single-cell RNA sequencing of nasal surgical and scraping samples from patients with chronic rhinosinusitis. (Source: Journal of Allergy and Clinical Immunology)

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