Σάββατο 8 Δεκεμβρίου 2018

Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans.

Conclusion: This species difference in PTX distribution and elimination hinders a simple direct extrapolation from animals to humans. Therefore, species difference in drug distribution and elimination should be carefully assessed during translational drug development. PMID: 30519122 [PubMed] (Source: Clinical Pharmacology: Advances and Applications)

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