3D‐ASL perfusion correlates with VEGF expression and overall survival in glioma patients: Comparison of quantitative perfusion and pathology on accurate spatial location‐matched basis

Background

There is a need for an imaging‐based tool for measuring vascular endothelial growth factor (VEGF) expression and overall survival (OS) in patients with glioma.

Purpose

To assess the correlation between cerebral blood flow (CBF), measured by 3D pseudo‐continuous arterial spin‐labeling (3D‐ASL), and VEGF expression in gliomas on the basis of coregistered localized biopsy, and investigate whether CBF correlated with survival month (SM) in glioma patients.

Study Type

Prospective cohort.

Subjects

Thirty‐seven patients with gliomas from whom 63 biopsy specimens were obtained.

Sequence

3D‐ASL acquired with a 3.0T MR unit.

Assessment

Biopsy specimens were grouped as high‐grade (HGG) or low‐grade glioma (LGG). CBF measurements were spatially matched with VEGF expression by coregistered localized biopsies, and the CBF value was correlated with quantitative VEGF expression for each specimen. Patients' survival information was derived and connected with CBF.

Statistical Tests

Patients' OS was analyzed by Kaplan–Meier and Cox‐regression methods. VEGF expression and CBF were compared in both LGG and HGG. The Spearman rank correlation was calculated for CBF and VEGF expression, SM. Significance level, P < 0.05.

Results

CBF‐derived 3D‐ASL positively correlated significantly with VEGF expression in both LGG (31 specimens) and HGG (32 specimens), r = 0.604 (P < 0.001) and r = 0.665 (P < 0.001), respectively. LGG and HGG together gave a correlation coefficient r = 0.728 (P < 0.001). Median survival for LGG and HGG patients was 34.19 and 17.17 months, respectively (P = 0.037); CBF value negatively correlated significantly with SM with r = –0.714 (P < 0.001) regardless of glioma grade. CBF was an independent risk factor for OS with HR = 1.027 (P = 0.044), 1.028 (P = 0.010) for univariate/multivariate regression analysis.

Data Conclusion

CBF determined by 3D‐ASL correlates with VEGF expression in glioma and is an independent risk factor for OS in these patients.

Level of Evidence: 1

Technical Efficacy: Stage 3

J. Magn. Reson. Imaging 2019.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SZQk91