Complexities in analyzing human basophil responses to autoantibodies to IgE or Fc εRI

Secretion of cytoplasmic granules (ie, degranulation) and production of other mediators not stored in granules (eg, leukotrienes, prostaglandins, and diverse cytokines) by mast cells and basophils activated through Fc εRI play key roles in diverse IgE-mediated immune responses, including asthma, hay fever, food allergies, and anaphylaxis.1,2 In both mast cells and basophils, secretory granule structure is thought to reflect in part electrostatic complexes between proteases (positively charged) and proteoglycans (negatively charged), which associate with and thereby help store multiple bioactive molecules, including histamine and certain cytokines. (Source: Journal of Allergy and Clinical Immunology)

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