Fungal biofilms in sinonasal polyposis: The role of fungal agents is notable?

Publication date: Available online 29 January 2019

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Navid Nourizadeh, Akram Adabizadeh, Hossein Zarrinfar, Mohammadreza Majidi, Amir Hosein Jafarian, Mohammad Javad Najafzadeh

Abstract

Chronic rhinosinusitis (CRS) is known by the inflammation of the sinonasal mucosa. Limited data are available on the fungal biofilms in CRS. This study aimed to investigate the role of fungal agents in sinonasal polyposis, and also to identify the dominant fungal pathogens by PCR and mycological studies. Sixty sinonasal biopsy specimens were examined; 31 sinonasal polyposis (SNP) as the study group and 29 concha bullosa without any history of chronic rhinosinusitis as the control. The specimens underwent histopathological examination for bacterial and fungal biofilms; routine mycological methods and then PCR using the internal transcribed spacer (ITS) region. Four (12.9%) specimens of the SNP group had a positive KOH preparation for fungal elements. The positive culture for Aspergillus flavus was obtained in 5 (16%) cases and one control. The identified isolates included one Cryptococcus magnus and two Penicillium chrysogenum in the study group and one P. chrysogenum in the control group. The fungal agents didn't have a significant role in the etiopathology of the SNP. Moreover, the results of mycological and histopathological methods had not any agreement with the molecular technique in CRS.

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