Differentiating supraclavicular from gluteal adipose tissue based on simultaneous PDFF and T2* mapping using a 20‐echo gradient‐echo acquisition

Background

Adipose tissue (AT) can be classified into white and brown/beige subtypes. Chemical shift encoding‐based water–fat MRI‐techniques allowing simultaneous mapping of proton density fat fraction (PDFF) and T₂* result in a lower PDFF and a shorter T₂* in brown compared with white AT. However, AT T₂* values vary widely in the literature and are primarily based on 6‐echo data. Increasing the number of echoes in a multiecho gradient‐echo acquisition is expected to increase the precision of AT T₂* mapping.

Purpose

1) To mitigate issues of current T₂*‐measurement techniques through experimental design, and 2) to investigate gluteal and supraclavicular AT T₂* and PDFF and their relationship using a 20‐echo gradient‐echo acquisition.

Study Type

Prospective.

Subjects

Twenty‐one healthy subjects.

Field Strength/Sequence Assessment

First, a ground truth signal evolution was simulated from a single‐T₂* water–fat model. Second, a time‐interleaved 20‐echo gradient‐echo sequence with monopolar gradients of neck and abdomen/pelvis at 3 T was performed in vivo to determine supraclavicular and gluteal PDFF and T₂*. Complex‐based water–fat separation was performed for the first 6 echoes and the full 20 echoes. AT depots were segmented.

Statistical Tests

Mann‐Whitney test, Wilcoxon signed‐rank test and simple linear regression analysis.

Results

Both PDFF and T₂* differed significantly between supraclavicular and gluteal AT with 6 and 20 echoes (PDFF: P < 0.0001 each, T₂*: P = 0.03 / P < 0.0001 for 6/20 echoes). 6‐echo T₂* demonstrated higher standard deviations and broader ranges than 20‐echo T₂*. Regression analyses revealed a strong relationship between PDFF and T₂* values per AT compartment (R² = 0.63 supraclavicular, R² = 0.86 gluteal, P < 0.0001 each).

Data Conclusion

The present findings suggest that an increase in the number of sampled echoes beyond 6 does not affect AT PDFF quantification, whereas AT T₂* is considerably affected. Thus, a 20‐echo gradient‐echo acquisition enables a multiparametric analysis of both AT PDFF and T₂* and may therefore improve MR‐based differentiation between white and brown fat.

Level of Evidence: 2

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2019.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2B53omx