Publication date: Available online 16 January 2019
Source: Academic Radiology
Author(s): Kenji Ito, Chigumi Ohtsuka, Kunihiro Yoshioka, Tetsuya Maeda, Suguru Yokosawa, Futoshi Mori, Tsuyoshi Matsuda, Yasuo Terayama, Makoto Sasaki
Rationale and Objective
Differentiation between multiple system atrophy (MSA) and other spinocerebellar degenerations showing cerebellar ataxia is often difficult. Hence, we investigated whether magnetic resonance diffusion kurtosis imaging (DKI) could detect pathological changes that occur in these patients and be used for differential diagnosis.
Methods
Thirty-six subjects (12 patients with MSA accompanied by predominant cerebellar ataxia [MSA-C], 10 patients with spinocerebellar ataxias [SCAs] or sporadic adult-onset ataxia of unknown etiology [SAOA], and 14 healthy controls) were examined using 1.5- or 3-T magnetic resonance scanners. From the DKI data, the mean kurtosis, fractional anisotropy, and mean diffusivity values of the pontine crossing tract (PCT), middle cerebellar peduncle, and cerebellum were automatically measured, and the ratios against the values of the corpus callosum were calculated.
Results
We found significant decreases in mean kurtosis and fractional anisotropy ratios in the PCT and middle cerebellar peduncle, and a significant increase in the mean diffusivity ratio in the PCT in the MSA-C group, as compared with the SCA/SAOA and control groups (p < 0.027–0.001). Among these metrics, there were no significant differences in the diagnostic performance. By contrast, the ratios in the cerebellum showed no significant differences between the MSA-C and SCA/SAOA groups but were significantly altered when compared with the controls (p < 0.001).
Conclusion
Quantitative DKI analyses can be used to differentiate between patients with MSA-C and those with SCA/SAOA.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FALz1S
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