Pharmacokinetic variation

Publication date: Available online 17 January 2019

Source: Anaesthesia & Intensive Care Medicine

Author(s): Danielle V. Eusuf, Elizabeth Thomas

Abstract

Pharmacokinetics is the study of how the body handles an administered drug, including absorption, distribution, metabolism and excretion. Pharmacokinetic variation is when there is variability in the drug concentration at the effector site after administration of a standard dose. This can result in one dose of a drug being ineffective in one patient, but potentially toxic with unwanted side effects in another. There are four factors which are responsible for pharmacokinetic variation: absorption, distribution, metabolism and excretion. This article will review how physiological, pathological and pharmacological processes can influence all of these factors.

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