Ultrastructural and optical characteristics of cancer cells treated by a nanotechnology based chemo-photothermal therapy method

Publication date: Available online 14 January 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Zahra Alamzadeh, Jaber Beik, Vahid Pirhajati Mahabadi, Ali Abbasian Ardakani, Alireza Ghader, S. Kamran Kamrava, Amin Shiralizadeh Dezfuli, Habib Ghaznavi, Ali Shakeri-ZadehAbstractThe current chemotherapy method demonstrates the need for improvement in terms of efficacy and safety. Given the beneficiary effect of heat in combination with chemotherapy, the purpose of this study is to develop a multifunctional nanoplatform by co-incorporating gold nanoparticles (AuNPs) as photothermal agent and cisplatin as anticancer drug into alginate hydrogel (named as ACA) to enable concurrent thermo-chemotherapy. The in vitro cytotoxicity experiment showed that the as-developed nano...

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