Binding Interaction of Juglone with Lysozyme: Spectroscopic Studies Aided by In Silico Calculations

Publication date: Available online 21 February 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Saumen Saha, Joydeep ChowdhuryAbstractBinding interactions between the drug Juglone (JUG) and Lysozyme (LYZ) have been explored in details from spectroscopic studies aided by in silico calculations. UV–Vis, steady state and time resolved fluorescence spectroscopic studies indicate the formation of LYZ–JUG complex in the ground state. Quenching of corrected fluorescence spectra of LYZ in presence of JUG at varied concentrations in different temperature range have been estimated from Stern–Volmer (SV) plots. Time resolved fluorescence spectroscopic studies confirm the mechanism of quenching to be of static type. Binding constant associated with the LYZ–JUG comple...

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