Urine eosinophil-derived neurotoxin declines following mepolizumab treatment in subjects with Eosinophilic Granulomatosis with Polyangiitis

Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a vasculitic disorder associated with elevated blood and tissue eosinophilia. Attempts to define biomarkers that predict disease activity or relapse in EGPA have proven difficult, and blood absolute eosinophil count (AEC) may not accurately reflect tissue eosinophilia. Although blood and urine levels of eosinophil granule proteins (EGP) correlate with markers of eosinophil activation in other eosinophilic disorders, little is known about their utility in monitoring disease activity in EGPA. (Source: Journal of Allergy and Clinical Immunology)

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