Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

Publication date: Available online 25 October 2018Source: CellAuthor(s): Yushi Yao, Mangalakumari Jeyanathan, Siamak Haddadi, Nicole G. Barra, Maryam Vaseghi-Shanjani, Daniela Damjanovic, Rocky Lai, Sam Afkhami, Yonghong Chen, Anna Dvorkin-Gheva, Clinton S. Robbins, Jonathan D. Schertzer, Zhou XingSummaryInnate immune memory is an emerging area of research. However, innate immune memory at major mucosal sites remains poorly understood. Here, we show that respiratory viral infection induces long-lasting memory alveolar macrophages (AMs). Memory AMs are programed to express high MHC II, a defense-ready gene signature, and increased glycolytic metabolism, and produce, upon re-stimulation, neutrophil chemokines. Using a multitude of approaches, we reveal that the priming, but not maintenance, ...

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