A one-day, 90-minute aspirin challenge and desensitization protocol in aspirin-exacerbated respiratory disease

ConclusionsPatients with AERD on a stable asthma regimen and with a baseline FEV1 >70% can be safely desensitized to aspirin using a 90-minute dose escalation protocol, starting at a dose of 40.5mg, and defining desensitization as tolerance of the repeated provocation dose and at least one subsequent aspirin dose, bringing total cumulative daily dose to ≥325mg. This protocol can routinely be completed in one day.Updating the current aspirin challenge and desensitization guidelines to include these three key elements will allow for maintaining an exceptional safety profile while increasing efficiency of this procedure. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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