Skin ‐homing CD8+ T cells preferentially express GPI‐anchored peptidase inhibitor 16, an inhibitor of cathepsin K

This study demonstrates robust association of cell surface peptidase inhibitor 16 (PI16) with skin ‐homing CD8+ T  cells. Human PI16 inhibits cathepsin K, but does not bind to other inflammatory skin proteases. PI16 persists on skin‐resident CD8+ T cells, but their reactivation induces rapid elimination of PI16 from the cell surface . AbstractThis study sought to identify novel CD8+ T  cell homing markers by studying acute graft versus host disease (aGvHD), typically involving increased T cell homing to the skin and gut. FACS‐sorted skin‐homing (CD8β+/CLA+), gut ‐homing (CD8β+/integrin β7+), and reference (CD8 β+/CLA–/integrin β7–) T  cells were compared in patients affected by cutaneous and/or gastrointestinal aGVHD. Microarray analysis, qPCR, and flow cytometry ...

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