T ‐Helper 2 Lymphocyte Immunophenotype Is Associated With Iatrogenic Laryngotracheal Stenosis

ConclusionCD3/CD4  + T‐helper lymphocytes and the proinflammatory cytokine IL‐4 are associated with iLTS. The association of a TH2 immunophenotype with iLTS is consistent with findings in other fibroinflammatory disorders. The murine results reveal that the inflammatory infiltrate precedes the development of fibrosis. However, human iLTS specimens with well ‐developed fibrosis also contain a marked chronic inflammatory infiltrate, suggesting that the continued release of IL‐4 by T‐helper lymphocytes may continue to propagate iLTS.Level of EvidenceNA.Laryngoscope, 2018 (Source: The Laryngoscope)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B8viOT