(1 → 3) β-Glucan induces multimodal toxicity responses in parallel exposures of model human lung epithelial cells and immature macrophage

AbstractMany epidemiological studies have associated bioaerosol exposures with a variety of adverse health effects; however, the role of bioaerosol components in the development and manifestation of hypersensitivity and non-infectious respiratory diseases remains unclear. Despite many studies which have examined allergic responses to bioaerosols, less is known about non-allergenic effects. In order to elucidate the mechanisms by which bioaerosols can exert non-atopic stresses on a cellular level, there is a need for improving existing in vitro approaches. In response, a cohort of toxicology assays were optimized to create a robust analytical suite for studying the effects that biogenic atmospheric pollutants generate on two model human lung cell lines (A549 epithelial line and GDM-1 immatu...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UFwWzq